Understanding speech in noise after correction of congenital unilateral aural atresia: Effects of age in the emergence of binaural squelch but not in use of head-shadow

Gray, Lincoln; Kesser, Bradley W.; Cole, Erika Diane

doi:10.1016/j.ijporl.2009.05.024

Cited by 52 publications

(52 citation statements)

References 43 publications

(61 reference statements)

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“…Similar decrements in binaural processing have also been demonstrated in children with reversible CHL secondary to aural atresia that has been surgically corrected (Gray et al 2009;Wilmington et al 1994). These shared abnormalities in perceptual outcomes of early reversible CHL suggest a causative role of developmental auditory deprivation in later perception regardless of the specific mechanisms that underlie the conductive hearing loss.…”

supporting

confidence: 61%

Evaluating the Perceptual and Pathophysiological Consequences of Auditory Deprivation in Early Postnatal Life: A Comparison of Basic and Clinical Studies

Whitton

Polley

2011

JARO

115

130

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Decades of clinical and basic research in visual system development have shown that degraded or imbalanced visual inputs can induce a long-lasting visual impairment called amblyopia. In the auditory domain, it is well established that inducing a conductive hearing loss (CHL) in young laboratory animals is associated with a panoply of central auditory system irregularities, ranging from cellular morphology to behavior. Human auditory deprivation, in the form of otitis media (OM), is tremendously common in young children, yet the evidence linking a history of OM to long-lasting auditory processing impairments has been equivocal for decades. Here, we review the apparent discrepancies in the clinical and basic auditory literature and provide a meta-analysis to show that the evidence for human amblyaudia, the auditory analog of amblyopia, is considerably more compelling than is generally believed. We argue that a major cause for this discrepancy is the fact that most clinical studies attempt to link central auditory deficits to a history of middle ear pathology, when the primary risk factor for brain-based developmental impairments such as amblyopia and amblyaudia is whether the afferent sensory signal is degraded during critical periods of brain development. Accordingly, clinical studies that target the subset of children with a history of OM that is also accompanied by elevated hearing thresholds consistently identify perceptual and physiological deficits that can endure for years after peripheral hearing is audiometrically normal, in keeping with the animal studies on CHL. These studies suggest that infants with OM severe enough to cause degraded afferent signal transmission (e.g., CHL) are particularly at risk to develop lasting central auditory impairments. We propose some practical guidelines to identify at-risk infants and test for the positive expression of amblyaudia in older children.

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supporting

confidence: 61%

Evaluating the Perceptual and Pathophysiological Consequences of Auditory Deprivation in Early Postnatal Life: A Comparison of Basic and Clinical Studies

Whitton

Polley

2011

JARO

115

130

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“…Results from the current study indicate that individual variability in the quality of phase-locked frequency representation contributes to behavioral BMLD variance in young, normal-hearing adults. Various populations, such as cochlear implant users (Kan and Litovsky 2015;Lu et al 2010) and individuals with corrected unilateral aural atresia (Gray et al 2009) have binaural deficits; approaches reported from the present study may help to explain individual differences in binaural performance. CLINARD ET AL.…”

Section: Neurophonics and Binaural Processingmentioning

confidence: 52%

Neural Correlates of the Binaural Masking Level Difference in Human Frequency-Following Responses

Clinard

Hodgson

Scherer

2016

JARO

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The binaural masking level difference (BMLD) is an auditory phenomenon where binaural tone-in-noise detection is improved when the phase of either signal or noise is inverted in one of the ears (SN or SN, respectively), relative to detection when signal and noise are in identical phase at each ear (SN). Processing related to BMLDs and interaural time differences has been confirmed in the auditory brainstem of non-human mammals; in the human auditory brainstem, phase-locked neural responses elicited by BMLD stimuli have not been systematically examined across signal-to-noise ratio. Behavioral and physiological testing was performed in three binaural stimulus conditions: SN, SN, and SN. BMLDs at 500 Hz were obtained from 14 young, normal-hearing adults (ages 21-26). Physiological BMLDs used the frequency-following response (FFR), a scalp-recorded auditory evoked potential dependent on sustained phase-locked neural activity; FFR tone-in-noise detection thresholds were used to calculate physiological BMLDs. FFR BMLDs were significantly smaller (poorer) than behavioral BMLDs, and FFR BMLDs did not reflect a physiological release from masking, on average. Raw FFR amplitude showed substantial reductions in the SN condition relative to SN and SN conditions, consistent with negative effects of phase summation from left and right ear FFRs. FFR amplitude differences between stimulus conditions (e.g., SN amplitude-SN amplitude) were significantly predictive of behavioral SN BMLDs; individuals with larger amplitude differences had larger (better) behavioral B MLDs and individuals with smaller amplitude differences had smaller (poorer) behavioral B MLDs. These data indicate a role for sustained phase-locked neural activity in BMLDs of humans and are the first to show predictive relationships between behavioral BMLDs and human brainstem responses.

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“…Furthermore, unilateral CHL during development can impair binaural processing and speech detection in noise (Clements and Kelly, 1978;Knudsen et al, 1984aKnudsen et al, , 1984bMoore et al, 1999;Parsons et al, 1999;King et al, 2000). Longer durations of unilateral CHL, due to the congenital absence of an ear canal, are associated with a poorer ability to understand speech in the presence of noise after corrective surgery, suggesting termination of the sensitive period for recovery (Gray et al, 2009).…”

Section: Age-dependent Effect Of Hearing Loss Onsetmentioning

confidence: 99%

A Sensitive Period for the Impact of Hearing Loss on Auditory Perception

Buran¹,

Sarro²,

Manno³

et al. 2014

J. Neurosci.

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Manipulations of the sensory environment typically induce greater changes to the developing nervous system than they do in adulthood. The relevance of these neural changes can be evaluated by examining the age-dependent effects of sensory experience on quantitative measures of perception. Here, we measured frequency modulation (FM) detection thresholds in adult gerbils and investigated whether diminished auditory experience during development or in adulthood influenced perceptual performance. Bilateral conductive hearing loss (CHL) of Ϸ30 dB was induced either at postnatal day 10 or after sexual maturation. All animals were then trained as adults to detect a 5 Hz FM embedded in a continuous 4 kHz tone. FM detection thresholds were defined as the minimum deviation from the carrier frequency that the animal could reliably detect. Normal-hearing animals displayed FM thresholds of 25 Hz. Inducing CHL, either in juvenile or adult animals, led to a deficit in FM detection. However, this deficit was greater for juvenile onset hearing loss (89 Hz) relative to adult onset hearing loss (64 Hz). The effects could not be attributed to sensation level, nor were they correlated with proxies for attention. The thresholds displayed by CHL animals were correlated with shallower psychometric function slopes, suggesting that hearing loss was associated with greater variance of the decision variable, consistent with increased internal noise. The results show that decreased auditory experience has a greater impact on perceptual skills when initiated at an early age and raises the possibility that altered development of CNS synapses may play a causative role.

show abstract

Understanding speech in noise after correction of congenital unilateral aural atresia: Effects of age in the emergence of binaural squelch but not in use of head-shadow

Cited by 52 publications

References 43 publications

Evaluating the Perceptual and Pathophysiological Consequences of Auditory Deprivation in Early Postnatal Life: A Comparison of Basic and Clinical Studies

Evaluating the Perceptual and Pathophysiological Consequences of Auditory Deprivation in Early Postnatal Life: A Comparison of Basic and Clinical Studies

Neural Correlates of the Binaural Masking Level Difference in Human Frequency-Following Responses

A Sensitive Period for the Impact of Hearing Loss on Auditory Perception

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