Understanding Propensity Score Analyses

Lalani, Nafisha; Jimenez, Rachel; Yeap, Beow Y.

doi:10.1016/j.ijrobp.2020.02.638

Cited by 32 publications

(32 citation statements)

References 9 publications

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“…We performed adjusted analyses using a multiple linear regression model and IPTW using the propensity score estimated via logistic regression. The outcome model used in the IPTW analysis was a linear regression of outcome on BCT or mastectomy, weighted by the estimated propensity score [44,45]…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the impact of specific patient and tumor characteristics (e.g., age, tumor grade or size, lymph node status, and the receipt of endocrine therapy and systemic therapy) were adjusted with the use of a rigorous approach to reduce the effects of confounding in the estimation of the type of local treatment effect. However, we acknowledge the limitations of the propensity score analysis and IPTW-matching method, especially that there was no adjustment for the impact of all baseline characteristics [45]. In addition, a comparison of the results of patients with stage I-IIA EBC and treated with mastectomy followed by postoperative radiation therapy would certainly add value to our research.…”

Section: Discussionmentioning

confidence: 99%

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Improved Survival after Breast-Conserving Therapy Compared with Mastectomy in Stage I-IIA Breast Cancer

Ratoša

Plavc

Pislar

et al. 2021

Cancers

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In the current study, we sought to compare survival outcomes after breast-conserving therapy (BCT) or mastectomy alone in patients with stage I-IIA breast cancer, whose tumors are typically suitable for both locoregional treatments. The study cohort consisted of 1360 patients with stage I-IIA (T1–2N0 or T0–1N1) breast cancer diagnosed between 2001 and 2013 and treated with either BCT (n = 1021, 75.1%) or mastectomy alone (n = 339, 24.9%). Median follow-ups for disease-free survival (DFS) and overall survival (OS) were 6.9 years (range, 0.3–15.9) and 7.5 years (range, 0.2–25.9), respectively. Fifteen (1.1%), 14 (1.0%) and 48 (3.5%) patients experienced local, regional, and distant relapse, respectively. For the whole cohort of patients, the estimated 5-year DFS and OS were 96% and 97%, respectively. After stratification based on the type of local treatment, the estimated 5-year DFS for BCT was 97%, while it was 91% (p < 0.001) for mastectomy-only treatment. Inverse probability of treatment weighting matching based on confounding confirmed that mastectomy was associated with worse DFS (HR 2.839, 95% CI 1.760–4.579, p < 0.0001), but not with OS (HR 1.455, 95% CI 0.844–2.511, p = 0.177). In our study, BCT was shown to have improved disease-specific outcomes compared to mastectomy alone, emphasizing the important role of adjuvant treatments, including postoperative radiation therapy, in patients with early-stage breast cancer at diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Improved Survival after Breast-Conserving Therapy Compared with Mastectomy in Stage I-IIA Breast Cancer

Ratoša

Plavc

Pislar

et al. 2021

Cancers

View full text Add to dashboard Cite

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“…balanced confounders or statements of causality [20]. In light of the clinical reality that SCLC patients treated with SRS would often be highly selected, even after propensity score matching it is likely that that biases from uncontrolled and unmeasured confounding would remain.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic radiosurgery (SRS) – A new normal for small cell lung cancer?

Pereira

Slotman²,

Rusthoven

et al. 2020

Clinical and Translational Radiation Oncology

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“…We adopted a propensity score (PS) approach and used PS weighting (PSW) as the framework for analyses as advocated in the literature. 19 , 20 , 21 , 22 We estimated the probability of receiving a high radiotherapy dose (vs. standard dose) with a logistic regression model based on all the above covariates, and then assessed the balance of covariates between groups after PSW using overlap weight 23 via the standardized difference (SDif) rather than the chi‐square or t ‐test. 19 , 20 We compared the hazard ratio (HR) of death between the group A and group B groups during the entire follow‐up period via Cox proportional hazards model in the weighted sample for point estimation and used the bootstrap method to estimate the 95% confidence interval (95% CI).…”

Section: Methodsmentioning

confidence: 99%

Optimal radiotherapy dose in cervical esophageal squamous cell carcinoma patients treated with definitive concurrent chemoradiotherapy: A population based study

Li¹,

Chen

Chou

et al. 2021

Thoracic Cancer

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Background: The optimal radiotherapy dose for locally advanced cervical esophageal squamous cell carcinoma (C-ESqCC) treated with definitive concurrent chemoradiotherapy (dCCRT) is unclear. Here, we aimed to compare the survival of those treated with high dose versus standard dose via a population based approach. Methods: Eligible C-ESqCC patients diagnosed between 2011 and 2017 were identified via the Taiwan Cancer Registry. We used propensity score (PS) weighting to balance observable potential confounders between groups. The hazard ratio (HR) of death and incidence of esophageal cancer mortality (IECM) were compared between high (60-70 Gy) and standard dose (50-50.4 Gy). We also evaluated the outcome in supplementary analyses via alternative approaches. Results: Our primary analysis consisted of 141 patients in whom covariates were well balanced after PS weighting. The HR of death when high dose was compared with standard dose was 0.65 (95% confidence interval [CI]: 0.4-1.03, p = 0.07). The HR of IECM was 0.74 (p = 0.45). The HR of OS remained similarly insignificant in supplementary analyses. Conclusions: We observed a trend in favor of high radiotherapy dose versus standard dose for C-ESqCC treated with dCCRT in this population-based nonrandomized study. Further studies are needed to confirm the findings of the study.

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Understanding Propensity Score Analyses

Cited by 32 publications

References 9 publications

Improved Survival after Breast-Conserving Therapy Compared with Mastectomy in Stage I-IIA Breast Cancer

Improved Survival after Breast-Conserving Therapy Compared with Mastectomy in Stage I-IIA Breast Cancer

Stereotactic radiosurgery (SRS) – A new normal for small cell lung cancer?

Optimal radiotherapy dose in cervical esophageal squamous cell carcinoma patients treated with definitive concurrent chemoradiotherapy: A population based study

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