Understanding organotropism in cancer metastasis using microphysiological systems

Ko, Jihoon; Song, Jiyoung; Lee, Yedam; Choi, Nakwon; Kim, Hong Nam

doi:10.1039/d3lc00889d

Cited by 2 publications

(2 citation statements)

References 160 publications

(181 reference statements)

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“…Consequently, there is a large emphasis on promoting vasculogenesis within models to improve the physiological relevancy, accuracy and increase the information gained from in vitro models over a longer period. There are 3 distinct designs to fabricate vascularisation within MPS: endothelial barrier, template-based vasculature and self-assembled networks [153].…”

Section: Vascularisationmentioning

confidence: 99%

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The use of microphysiological systems to model metastatic cancer

Jackson,

Green,

English

et al. 2024

Biofabrication

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Cancer is one of the leading causes of death in the 21st century with metastasis of cancer attributing to 90% of cancer-related deaths. Therefore, to improve patient outcomes there is a need for better preclinical models to increase the success of translation of oncological therapies into the clinic. Current traditional static in vitro models lack a perfusable network which is critical to overcome the diffusional mass transfer limit to provide a mechanism for the exchange of essential nutrients and waste removal, and increase their physiological relevance. Furthermore, these models typically lack cellular heterogeneity and key components of the immune system and tumour microenvironment. This review explores rapidly developing strategies utilising perfusable microphysiological systems (MPS) for investigating cancer cell metastasis. In this review we initially outline the mechanisms of cancer metastasis, highlighting key steps and identifying the current gaps in our understanding of the metastatic cascade, exploring MPS focused on investigating the individual steps of the metastatic cascade before detailing the latest MPS which can investigate multiple components of the cascade. This review then focuses on the factors which can affect the performance of an MPS designed for cancer applications with a final discussion summarising the challenges and future directions for the use of MPS for cancer models.

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Section: Vascularisationmentioning

confidence: 99%

“…Endothelial barrier models do not wholly recapitulate the 3D environment and are termed as pseudo-3D [153]. Therefore, they are limited to replicating the endothelial lining within a vessel and not a whole vessel construct.…”

Section: Vascularisationmentioning

confidence: 99%

The use of microphysiological systems to model metastatic cancer

Jackson,

Green,

English

et al. 2024

Biofabrication

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An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

Parihar,

Sunildutt,

Rahim

et al. 2024

Advanced Therapeutics

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Vascularized tumor on a chip (VToC) entails emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor biology, evaluation of drug efficacy, and anticipation of patient responses to therapies. Compared to conventional ones, VToC systems hold advantages by creating a milieu where physiological conditions for investigating tumor‐host interactions are pivotal in tumor advancement/therapy resilience. Nevertheless, VToC models confront limitations encompassing vascular network replication, biological fidelity, mechanical/chemical integrity, and intricacies of architectural design. Thus, drawbacks inherent to prevailing VToC models' intricacies, attributes, and vascular network establishment are imperative. This systematic review focuses on the recent advancements, technologies explored for incorporating VToC models, & vascularization approaches for investigation, and factors/parameters affecting complex tumor microenvironments in VToC models, along with the futuristic approach for the design strategies, fabrication techniques, understanding of vascular network, also VToC models with spheroid. A comprehensive analysis of VToC based on their limitations for a practical approach highlights the promising strategies for possible applications. This review will be essential regarding a complete overview of VToC models and the future direction toward developing efficient VToC models compared to the state‐of‐the‐art VToC.This article is protected by copyright. All rights reserved

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Understanding organotropism in cancer metastasis using microphysiological systems

Abstract: Organotropism is an important concept to explain the process of cancer metastasis. In this paper, we introduce microphysiological systems with simultaneous physiological relevance and high throughput to recapitulate the series of cancer progression.

Cited by 2 publications

References 160 publications

The use of microphysiological systems to model metastatic cancer

The use of microphysiological systems to model metastatic cancer

An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

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