Understanding Minoxidil-Induced Pericardial Effusion

Shafter, Ahmed M

doi:10.4172/2329-9517.1000323

Cited by 3 publications

(12 citation statements)

References 9 publications

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“…The differential diagnoses of pleuropericardial effusion and generalized anasarca include cardiac disease, hepatic disease, protein-calorie malnutrition, thyroid disease, obstructive sleep apnea, renal etiology, medications such as calcium channel blockers, corticosteroids, vasodilators, and malignant ascites [1,7]. For a patient with generalized anasarca, most diagnoses are made based on history and physical findings.…”

Section: Discussionmentioning

confidence: 99%

“…Minoxidil is an oral direct vasodilator antihypertensive agent that was approved in the 1970s for the treatment of RHTN [1,8]. RHTN is a medical condition in which a patient fails therapy management to three or more antihypertensive drugs at maximum dosage after exclusion of pseudohypertension [2].…”

Section: Discussionmentioning

confidence: 99%

“…Our patient in this case had been diagnosed with RHTN, prescribed minoxidil, but without a beta-blocking and diuretic agent, and was lost to follow-up with the medical provider. This could explain his pleuropericardial effusion and anasarca given that it is recommended that a therapeutic dose of beta-blockers along with a loop diuretic be given to decrease salt and water retention [1].…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism of fluid retention is a combination of dose-dependent, neurohormonal changes and renal hemodynamic [8]. The recommended starting dose is 5 mg per dose, and the maximum dose is 100 mg per day [1,3]. It can be titrated every three days by doubling the daily dose up to the maintenance range of 10-40 mg per day [1,3,8].…”

Section: Discussionmentioning

confidence: 99%

“…Resistant hypertension (RHTN) is a severe medical condition that is estimated to occur in 9-18% of patients with hypertension [1,2]. It is characterized by its lack of response to treatment with three or more antihypertensive medications, including a diuretic.…”

Section: Introductionmentioning

confidence: 99%

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Atypical Case of Minoxidil-Induced Generalized Anasarca and Pleuropericardial Effusion

Gbadamosi¹,

Melvin²,

López³

2021

Cureus

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Minoxidil is an antihypertensive medication used to control blood pressure that is resistant to three or more antihypertensive medications including diuretics. There have only been a few reported cases of minoxidilinduced pleuropericardial effusion with anasarca. Here, we discuss the case of a 70-year-old male with a history of uncontrolled hypertension who presented to the hospital with swelling of the extremities. He was on minoxidil 10 mg twice a day and complained of generalized body swelling and extremity pain with symptoms of dyspnea on exertion, paroxysmal nocturnal dyspnea, weight gain, abdominal distention, and intermittent, throbbing extremity pain (8/10). The patient denied a history of cardiac disease, pulmonary embolism, deep vein thrombosis, and malignancy. His vitals were stable with a blood pressure of 152/67 mmHg. The physical examination findings were significant for positive jugular vein pressure, bilateral crackles at the lung bases with abdominal distention, fluid thrill, and flank edema. The extremities showed pitting edema in the upper and lower extremities that were tender to palpation. Laboratory results were only significant for uremia and elevated brain natriuretic peptide. Electrocardiography, echocardiography, and CT of the chest and abdomen exhibited findings consistent with pericardial effusion, pleural effusion, abdominal ascites, and anasarca in the soft tissues of the axilla and chest wall. After discontinuation of minoxidil and starting intravenous diuretics, the patient showed clinical improvement. This case report reviews and explains that minoxidil-induced anasarca should be considered as a differential diagnosis in patients taking minoxidil as knowledge of this rare finding may lead to early diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Atypical Case of Minoxidil-Induced Generalized Anasarca and Pleuropericardial Effusion

Gbadamosi¹,

Melvin²,

López³

2021

Cureus

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Minoxidil-associated pericardial effusion and impending tamponade

Lew,

Amato

2023

Jaapa

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Drug-induced pericarditis

Alušík¹,

Paluch²

2022

Cor Vasa

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Léky vyvolané perikarditidy nejsou časté, ale závažné onemocnění, protože případná tamponáda perikardu může ohrozit život pacienta. Vzhledem k tomu, že nabídka nových léků se neustále rozšiřuje, zvyšuje se i podíl léčiv schopných perikarditidu vyvolat. Autoři vyhodnotili práce s touto tematikou uvedené v databázi PubMed a doplnili informacemi z databáze VigiBase. Ve svém článku autoři uvádějí současné poznatky o mechanismech vzniku i stupni rizika vzniku léky vyvolané perikarditidy. Uvádějí relevantní informace o jednotlivých lécích rozdělených do sedmi skupin. U některých léčiv je riziko vzniku perikarditidy vysoké a při léčbě těmito přípravky je nutné toto riziko brát v úvahu.

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Understanding Minoxidil-Induced Pericardial Effusion

Cited by 3 publications

References 9 publications

Atypical Case of Minoxidil-Induced Generalized Anasarca and Pleuropericardial Effusion

Atypical Case of Minoxidil-Induced Generalized Anasarca and Pleuropericardial Effusion

Minoxidil-associated pericardial effusion and impending tamponade

Drug-induced pericarditis

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