Understanding Microbiome Stability in a Changing World

Shade, Ashley

doi:10.1128/msystems.00157-17

Cited by 13 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the soils in Centralia were previously temperate, with no known exposure to prolonged high temperatures. Therefore, Centralia offers an interesting model for the examining the ecoevolution of microbial communities 17 .…”

Section: Main Textmentioning

confidence: 99%

Ecological selection for small microbial genomes along a temperate-to-thermal soil gradient

et al. 2018

Self Cite

View full text Add to dashboard Cite

doi: bioRxiv preprint supported under Contract No. DE-AC02-05CH11231. We thank Keara L. Grady and Sang-Hoon Lee for technical support and Susanna Yeh (REU-ACRES NSF Grant # 1560168) for assistance with soil metagenome curation from MG-RAST and analyses. Contributions AS and TCT conceived the study and conducted field work. JWS and TKD performed analyses, with direction and oversight by AS. JWS, AS and TKD contributed writing. All authors discussed results, and commented on and edited the manuscript.

show abstract

Section: Main Textmentioning

confidence: 99%

Ecological selection for small microbial genomes along a temperate-to-thermal soil gradient

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Host-associated microbiomes are increasingly recognized as ecological systems, where interactions among microbes and between microbes and their host are important for shaping community composition, structure, and function (1,2). As this understanding has developed, there has come a search for the ecological principles that define these communities (3,4). 5…”

Section: Introductionmentioning

confidence: 99%

Host immunity alters successional ecology and stability of the microbiome in a C. elegans model

Taylor

Vega

2020

Preprint

View full text Add to dashboard Cite

A growing body of data suggests that the microbiome of a species can vary considerably from individual to individual, but the reasons for this variation - and the consequences for the ecology of these communities – remain only partially explained. In mammals, the emerging picture is that the metabolic state and immune system status of the host affects the composition of the microbiome, but quantitative ecological microbiome studies are challenging to perform in higher organisms. Here we show that these phenomena can be quantitatively analyzed in the tractable nematode host Caenorhabditis elegans. Mutants in innate immunity, in particular the DAF-2/Insulin Growth Factor (IGF) pathway, are shown to contain a microbiome that differs from that of wild type nematodes. We analyze the underlying basis of these differences from the perspective of community ecology by comparing experimental observations to the predictions of a neutral sampling model and conclude that fundamental differences in microbiome ecology underlie the observed differences in microbiome composition. We test this hypothesis by introducing a minor perturbation to the colonization conditions, allowing us to assess stability of communities in different host strains. Our results show that altering host immunity changes the importance of inter-species interactions within the microbiome, resulting in differences in community composition and stability that emerge from these differences in host-microbe ecology.ImportanceHere we use a Caenorhabditis elegans microbiome model to demonstrate how genetic differences in innate immunity alter microbiome composition, diversity, and stability by changing the ecological processes that shape these communities. These results provide insight into the role of host genetics in controlling the ecology of host-associated microbiota, resulting in differences in community composition, successional trajectories, and response to perturbation.

show abstract

“…263 Her research is also focused on the dynamic nature of microbiomes and how environmental perturbations or man-made interventions can alter these dynamics. 262,264 Understanding these traits, mechanisms, and dynamics is important for developing plant probiotics for plant growth, insect control, and pathogen control.…”

Section: Plant Microbiome and Metaphenome Engineeringmentioning

confidence: 99%

Catalyzing Holistic Agriculture Innovation Through Industrial Biotechnology

Walker

Buhler

2020

Industrial Biotechnology

View full text Add to dashboard Cite

Understanding Microbiome Stability in a Changing World

Abstract: Microbiomes underpin biogeochemical processes, sustain the bases of food webs, and recycle carbon and nutrients. Thus, microbes are frontline players in determining ecosystem responses to environmental change.

Cited by 13 publications

References 14 publications

Ecological selection for small microbial genomes along a temperate-to-thermal soil gradient

Ecological selection for small microbial genomes along a temperate-to-thermal soil gradient

Host immunity alters successional ecology and stability of the microbiome in a C. elegans model

Catalyzing Holistic Agriculture Innovation Through Industrial Biotechnology

Contact Info

Product

Resources

About