Understanding mechanistic aspects and therapeutic potential of natural substances as anticancer agents

Deep, Aakash; Kumar, Davinder; Bansal, Nitin; Narasimhan, Balasubramanian; Marwaha, Rakesh Kumar; Sharma, Prabodh Chander

doi:10.1016/j.phyplu.2023.100418

Cited by 15 publications

(17 citation statements)

References 204 publications

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“…All azole derivatives (1,3,4-oxadiazole/thiadiazoles) were synthesized using the synthetic method shown in Scheme 1 (Table 1). In the first step, a mixture containing semi/thiosemicarbazide (2) and sodium acetate was added to water and stirred well, followed by the addition of substituted aldehydes (1) in methanol at room temperature to provide an intermediate solid residue. The residue was redissolved in 1,4-dioxane and the stirring was continued (4-6 h) at 80-85 °C with the addition of K2CO3 and iodine in sequence to obtain 2-Amino 1,3,4-oxadiazole/thiadiazole derivatives (3).…”

Section: Resultsmentioning

confidence: 99%

“…The final compounds (7) were obtained by reaction with thioglycolic acid (6) using a small quantity of zinc chloride as a catalyst. A variety of spectral techniques, i.e., FT-IR (KBr, cm −1 ), 1 H-NMR (DMSO-d6, 400 MHz, δ ppm), mass spectra, and elemental analysis, were used to confirm the structures of the From this perspective, 1,3,4-oxadiazole/thiadiazole conjugates in medicinal chemistry have been developed rapidly and represent a significant approach to address the various drawbacks associated with anticancer and antimicrobial drugs, such as drug toxicity, drug resistance, and other serious side effects [26][27][28]. The 1,3,4-thiadiazole and 1,3,4-oxadiazole conjugates have therefore been investigated extensively.…”

Section: Resultsmentioning

confidence: 99%

“…Throughout the world, cancer incidence and mortality rates are rising. Thus, this global burden of cancer, after cardiovascular diseases, is causing a significant decline in lifetimes and a rise in premature deaths [ 1 , 2 ]. Many different types of therapeutic approaches are being applied for the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

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2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential

et al. 2023

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In this innovative research, a novel series of thiazolidin-4-one analogues having a 1,3,4-oxadiazole/thiadiazole moiety were derived and the structures of all the newly obtained molecules were established using different physicochemical and analytical means (1H-NMR, FTIR, mass spectra, and elemental analyses). The synthesized molecules were then investigated for their antiproliferative, antimicrobial, and antioxidant potential. The cytotoxicity screening studies revealed that analogues D-1, D-6, D-15, and D-16 possessed comparable efficacy, within the IC50 range (1 to 7 μM), when taking doxorubicin as a reference drug (IC50 = 0.5 μM). The antimicrobial activity was assessed using different Gram-(+) and Gram-(−) bacterial and fungal strains and the results revealed that molecules D-2, D-4, D-6, D-19, and D-20 possessed potent activity against selective strains of microbes with MIC ranges of 3.58 to 8.74 µM. The antioxidant evaluation was performed using the DPPH assay and the screening results revealed that analogue D-16 was the most potent derivative (IC50 = 22.3 µM) when compared with the positive control, ascorbic acid (IC50 = 111.6 µM). Structure–activity relationship (SAR) studies of the synthesized novel derivatives revealed that para-substituted halogen and hydroxy derivatives have remarkable potential against the MCF-7 cancer cell line and antioxidant potential. Similarly, electron-withdrawing groups (Cl/NO2) and -donating groups at the para position possess moderate to promising antimicrobial potential.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential

et al. 2023

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“…The global Aloe vera hydrogel market was assessed at USD 337.7 million in 2022 and is expected to reach USD 712.3 million by 2032, at a compound annual growth rate (CAGR) of 7.8% from 2022 to 2032, higher than the estimated CAGR for the period 2017–2022 (of approximately 6%) [ 35 ]. Due to its composition, water (>98%) in the mucilaginous gel and ~2% minerals, vitamins, enzymes and polysaccharides (such as hemicellulose, cellulose, mannose derivatives, pectin, glucomannan and acemannan), Aloe vera possesses numerous antibacterial, antioxidant, antiviral, antiallergic, UV protection, cicatrizing, anti-inflammatory and antiviral therapeutic properties [ 36 , 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications

Chelu

Musuc

Aricov

et al. 2023

IJMS

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The present research aims to describe a new methodology to obtain biocompatible hydrogels based on Aloe vera used for wound healing applications. The properties of two hydrogels (differing in Aloe vera concentration, AV5 and AV10) prepared by an all-green synthesis method from raw, natural, renewable and bioavailable materials such as salicylic acid, allantoin and xanthan gum were investigated. The morphology of the Aloe vera based hydrogel biomaterials was studied by SEM analysis. The rheological properties of the hydrogels, as well as their cell viability, biocompatibility and cytotoxicity, were determined. The antibacterial activity of Aloe vera based hydrogels was evaluated both on Gram-positive, Staphylococcus aureus and on Gram-negative, Pseudomonas aeruginosa strains. The obtained novel green Aloe vera based hydrogels showed good antibacterial properties. In vitro scratch assay demonstrated the capacity of both AV5 and AV10 hydrogels to accelerate cell proliferation and migration and induce closure of a wounded area. A corroboration of all morphological, rheological, cytocompatibility and cell viability results indicates that this Aloe vera based hydrogel may be suitable for wound healing applications.

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“…Luteolin as anticancerNatural products have proven to be a valuable and potent reservoir of anticancer agents over the past few years through structural modifications or utilization of naturally occurring compounds as building blocks. These compounds hold remarkable promise for combating cancer and have contributed substantially to advancements in cancer therapy[50].…”

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confidence: 99%

The Protective Properties of Luteolin: A Comprehensive Review

Abdrabou,

Salama,

El-Naga

et al. 2024

Archives of Pharmaceutical Sciences Ain Shams University

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Luteolin, a flavone abundant in various plant-based foods, presents a multifaceted pharmacological profile with promising therapeutic implications. This review provides a comprehensive analysis of the pharmacokinetics of luteolin, elucidating its absorption, distribution, metabolism, and excretion properties. Additionally, the protective mechanisms of luteolin are presented, encompassing its anti-inflammatory, antioxidant, and anti-apoptotic properties, which have been demonstrated in various in vitro and in vivo models. Furthermore, the review explores the impact of luteolin on diverse disorders, including cardiovascular diseases, neurodegenerative disorders, cancer, and liver and kidney diseases. In addition, the synergistic effects of luteolin with conventional chemotherapeutic agents are discussed, shedding light on its potential in cancer therapy. Furthermore, we provide insights into ongoing clinical studies, emphasizing the need for more rigorous investigation to validate the therapeutic benefits of luteolin in human populations. Overall, luteolin emerges as a promising therapeutic candidate, warranting further research to unlock its full therapeutic potential and facilitate its clinical application in various disease contexts.

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Understanding mechanistic aspects and therapeutic potential of natural substances as anticancer agents

Cited by 15 publications

References 204 publications

2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential

2-Substituted-3-(5-Substituted-1,3,4-oxadiazol/thiadiazol-2-yl) Thiazolidin-4-one Derivatives: Synthesis, Anticancer, Antimicrobial, and Antioxidant Potential

Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications

The Protective Properties of Luteolin: A Comprehensive Review

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