“…For example, there are studies dealing with tumor DNA detection, also for methylation profiling, in liquid cytology samples from vagina and endocervix, including routinely collected cervical screening specimens, vaginal self-swab and tampons, and uterine lavage samples. Moreover, improvements in imaging methods are pursued to include refinements of TVS, Doppler flow, microbubble contrast-enhanced TVS, and photo-acoustic imaging, all of which allow high-resolution detection of angiogenesis with the potential to detect neovascularization in early cancers [ 26 , 27 , 28 ]. In addition, multi-omics technologies (genomics, transcriptomics, proteomics, and metabolomics) hold the possibility of discovering new informative BMs [ 29 , 30 ] in signature panels.…”