Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy
Lamei Wang,
Javier A. Villafuerte Gálvez,
Christina Lee
et al.
Abstract:Clostridioides difficile (C. difficile) is the predominant causative agent of nosocomial diarrhea worldwide. Infection with C. difficile occurs due to the secretion of large glycosylating toxin proteins, which can lead to toxic megacolon or mortality in susceptible hosts. A critical aspect of C. difficile's biology is its ability to persist asymptomatically within the human host. Individuals harboring asymptomatic colonization or experiencing a single episode of C. difficile infection (CDI) without recurrence … Show more
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