Understanding heterogeneous mechanisms of heart failure with preserved ejection fraction through cardiorenal mathematical modeling
Sanchita Basu,
Hongtao Yu,
Jonathan R. Murrow
et al.
Abstract:In contrast to heart failure (HF) with reduced ejection fraction (HFrEF), effective interventions for HF with preserved ejection fraction (HFpEF) have proven elusive, in part because it is a heterogeneous syndrome with incompletely understood pathophysiology. This study utilized mathematical modeling to evaluate mechanisms distinguishing HFpEF and HFrEF. HF was defined as a state of chronically elevated left ventricle end diastolic pressure (LVEDP > 20mmHg). First, using a previously developed cardiorenal m… Show more
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