Understanding flux switching in metabolic networks through an analysis of synthetic lethals
Sowmya Manojna Narasimha,
Tanisha Malpani,
Omkar S. Mohite
et al.
Abstract:Biological systems are robust and redundant. The redundancy can manifest as alternative metabolic pathways. Synthetic double lethals are pairs of reactions that, when deleted simultaneously, abrogate cell growth. However, removing one reaction allows the rerouting of metabolites through alternative pathways. Little is known about these hidden linkages between pathways. Understanding them in the context of pathogens is useful for therapeutic innovations. We propose a constraint-based optimisation approach to id… Show more
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