Understanding Cognitive Deficits in People with Coronary Heart Disease (CHD)

Abstract

Coronary heart disease (CHD) is one of the main cardiovascular diseases that can cause disability and death across the globe. Although previous research explored the links between CHD and cognitive deficits, only a subset of cognitive abilities was analyzed and a small clinical sample size was used. Thus, the aim of the current study is to assess how CHD can affect the cognitive domains of episodic memory, semantic verbal fluency, fluid reasoning, and numerical ability in a large cohort of participants from the United Kingdom. Results revealed that episodic memory, semantic verbal fluency, fluid reasoning, and numerical ability are negatively affected by CHD. Prevention and intervention should be developed to preserve cognitive abilities in people with CHD, but more studies should explore specific ways of doing so.

Association of beta-2-microglobulin, cystatin C and lipocalin-2 with stroke risk in the general Chinese population

“…B2M, lipocalin-2 and cystatin C have been shown to be associated with CHD [ 20 , 24 , 25 ]. CHD is also known to be associated with cognitive deficits [ 26 ]; in a large British cohort, episodic memory, semantic verbal fluency, fluid reasoning and numerical ability were inversely associated with CHD. Previous studies of polymorphisms did not provide evidence that cystatin C plays a role in the aetiology of CHD [ 9 , 27 , 28 ].…”