Understanding Chronic Aggression and Its Treatment in Children and Adolescents

Magalotti, Selena R.; Neudecker, Mandy; Zaraa, Solomon G.; McVoy, Molly

doi:10.1007/s11920-019-1105-1

Cited by 10 publications

(4 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, several limitations exist among available psychosocial and psychopharmacological treatment options regarding excessive aggression in terms of access, safety, efficacy, as well as patient and family preferences (Barzman & Findling, 2008;Magalotti, Neudecker, Zaraa, & McVoy, 2019;Pisano & Masi, 2020).…”

Section: These Interventions Include Parent Training [Supported By Thementioning

confidence: 99%

PROTOCOL: The efficacy of nutritional interventions in reducing childhood/youth aggressive and antisocial behavior: A systematic review and meta‐analysis

Konkolÿ Thege,

Kinzel,

Hartmann‐Boyce

et al. 2024

Campbell Systematic Reviews

View full text Add to dashboard Cite

This is a protocol for a Campbell systematic review of intervention effectiveness. The goal of this systematic review is to answer the following questions based on the available empirical evidence: Are there nutritional interventions (dietary manipulation, fortification or supplementation) that can reduce excessive aggression towards others in children/youth? If yes, how strong is their effect and is there a difference among the three intervention types? Are there nutritional interventions that can reduce antisocial behaviors in children/youth? If yes, how strong is their effect and is there a difference among the intervention types? Are there nutritional interventions that can reduce violent offending in children/youth? If yes, how strong is their effect and is there a difference among the intervention types? Are there nutritional interventions that can reduce non‐violent offending in children/youth? If yes, how strong is their effect and is there a difference among the intervention types? What implementation barriers and solutions to these exist in relation to the above nutritional interventions in children/youth?

show abstract

Section: These Interventions Include Parent Training [Supported By Thementioning

confidence: 99%

PROTOCOL: The efficacy of nutritional interventions in reducing childhood/youth aggressive and antisocial behavior: A systematic review and meta‐analysis

Konkolÿ Thege,

Kinzel,

Hartmann‐Boyce

et al. 2024

Campbell Systematic Reviews

View full text Add to dashboard Cite

show abstract

“…Aggressive behavior is one of the most common reasons for mental health referrals in children and adolescents [30][31][32], and can co-occur with a broad array of psychiatric and neurological illnesses, including ASD, intellectual disability, ADHD, conduct disorder, oppositional defiant disorder, disruptive mood dysregulation disorder, schizophrenia, epilepsy, anxiety, depression, and sleep disorders [33,34]. While impulsive aggression may not indicate any specific disorder, it is an important marker of severity for many psychiatric diseases [35].…”

Section: Comparison With Prior Work On 16p1311 Microduplicationmentioning

confidence: 99%

Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study

Li¹,

Hojlo²,

Chennuri³

et al. 2021

J Med Internet Res

View full text Add to dashboard Cite

Background 16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental and physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use a patient “self-phenotyping” survey to collect data directly from patients to further characterize the phenotypes of 16p13.11 microduplication syndrome. Objective This study aimed to (1) discover self-identified phenotypes in 16p13.11 microduplication syndrome that have been underrepresented in the scientific literature and (2) demonstrate that self-phenotyping tools are valuable sources of data for the medical and scientific communities. Methods As part of a large study to compare and evaluate patient self-phenotyping surveys, an online survey tool, Phenotypr, was developed for patients with rare disorders to self-report phenotypes. Participants with 16p13.11 microduplication syndrome were recruited through the Boston Children's Hospital 16p13.11 Registry. Either the caregiver, parent, or legal guardian of an affected child or the affected person (if aged 18 years or above) completed the survey. Results were securely transferred to a Research Electronic Data Capture database and aggregated for analysis. Results A total of 19 participants enrolled in the study. Notably, among the 19 participants, aggression and anxiety were mentioned by 3 (16%) and 4 (21%) participants, respectively, which is an increase over the numbers in previously published literature. Additionally, among the 19 participants, 3 (16%) had asthma and 2 (11%) had other immunological disorders, both of which have not been previously described in the syndrome. Conclusions Several phenotypes might be underrepresented in the previous 16p13.11 microduplication literature, and new possible phenotypes have been identified. Whenever possible, patients should continue to be referenced as a source of complete phenotyping data on their condition. Self-phenotyping may lead to a better understanding of the prevalence of phenotypes in genetic disorders and may identify previously unreported phenotypes.

show abstract

“…High levels of aggression can have significant costs to society and are one of the leading causes for youth seeking referrals to mental health (Magalotti et al, 2019). While aggression is not atypical during childhood development, maladaptive levels of aggression (i.e., overly frequent and intense) can lead to impaired social relationships, incarceration, and even death (Hendricks & Liu, 2012).…”

Section: Introductionmentioning

confidence: 99%

Cortical volume alterations in the limbic network in adolescents with high reactive aggression

Bashford-Largo,

Blair,

Blair

et al. 2024

Dev Psychopathol

View full text Add to dashboard Cite

Previous studies show aggression-related structural alterations in frontal and limbic brain regions. Most studies have focused on overall aggression, instead of its subtypes, and on specific regions instead of networks. This study aims to identify both brain networks and regions that are associated with reactive and proactive subtypes of aggression. Structural MRI data were collected from 340 adolescents (125 F/215 M) with a mean age of 16.29 (SD = 1.20). Aggression symptomology was indexed via the Reactive Proactive Aggression Questionnaire (RPQ). Freesurfer was used to estimate Cortical Volume (CV) from seven networks and regions within specific networks associated with aggression. Two multivariate analyses of covariance (MANCOVAs) were conducted on groups for low versus higher reactive and proactive RPQ scores. Our reactive aggression MANCOVA showed a main effect in CV [F(14,321) = 1.935, p = 0.022,ηp2 = 0.078] across all the 7-Networks. Unpacking this main effect revealed significant volumetric differences in the right Limbic Network (LN) (p = 0.029) and the Temporal Pole (p = 0.011), where adolescents in the higher reactive aggression group showed higher cortical volumes. Such findings are consistent with region/voxel-specific analyses that have associated atypical structure within the LN and reactive aggression. Moreover, the temporal pole is highly interconnected with regions important in the regulation and initiation of reactive aggression.

show abstract

Understanding Chronic Aggression and Its Treatment in Children and Adolescents

Cited by 10 publications

References 85 publications

PROTOCOL: The efficacy of nutritional interventions in reducing childhood/youth aggressive and antisocial behavior: A systematic review and meta‐analysis

PROTOCOL: The efficacy of nutritional interventions in reducing childhood/youth aggressive and antisocial behavior: A systematic review and meta‐analysis

Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study

Cortical volume alterations in the limbic network in adolescents with high reactive aggression

Contact Info

Product

Resources

About