JAMA Network Open published its inaugural edition in May 2018, and 2019 represents the first full calendar year of publication. Our mission is to be "an international, peer-reviewed, open access, general medical journal that publishes research on clinical care, innovation in health care, health policy, and global health across all health disciplines and countries for clinicians, investigators, and policy makers." We believe that the journal is clearly fulfilling this mission. We are grateful that JAMA Network Open has been embraced by investigators throughout the international community who have entrusted us to consider their work and readers who view our content, which is now published each business day. Submissions to JAMA Network Open steadily increased throughout 2019; as shown in the Table, 1-4 we received 2987 research manuscripts during 2019 and published 800, with an acceptance rate of 30%. We also published 177 Invited Author affiliations and article information are listed at the end of this article.