Understanding and Addressing Unique Needs of Diabetes in Asian Americans, Native Hawaiians, and Pacific Islanders

King, George L.; McNeely, Marguerite J.; Thorpe, Lorna E.; Mau, Marjorie; Ko, Jocelyn; Liu, Lenna L.; Sun, Angela; Hsu, William C.; Chow, Edward A.

doi:10.2337/dc12-0210

Cited by 106 publications

(119 citation statements)

References 33 publications

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“…The notion of genetic variability is particularly noteworthy in Asians, a population that exhibits a high prevalence of the BDNF SNP (around 70%) (22,23). Despite Asians having a significantly lower mean body mass index than other ethnic groups, studies have shown that the exposure of this population to a western-style HFD profoundly increases the risk of developing IR and type II diabetes by 1.5-2 fold, which is higher than other ethnic groups (45)(46)(47). In addition, a significantly higher incidence of undiagnosed diabetes in Asians (48) suggests that a treatment strategy targeting populations genetically at risk for developing obesity-associated metabolic dysfunction may be beneficial.…”

Section: M/mmentioning

confidence: 99%

Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant

Yang

Park

Cho

2018

Journal of Biological Chemistry

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Running title: CD36 inhibition improves metabolic dysfunction in obese miceKey words: CD36, diabetes, insulin resistance, obese, salvianolic acid B AbstractObesity-induced metabolic dysfunctions increase risk of vascular diseases including type II diabetes and stroke. While managing obesity is an interest to address the worldwide health problem, how genetic variability affects human obesity development and specific targets for obesity-related metabolic disease have not been thoroughly studied. A single nucleotide polymorphism (SNP) in the brain derived neurotropic factor (BDNF) gene that results in the substitution of a valine to a methionine at codon 66 (val66met) occurs with a high frequency in humans. This study addressed the effect of genetic variability in developing obesity and the efficacy of the inhibition of CD36, a multifunctional receptor implicated in obesity and insulin resistance, in wild-type mice and mice with the bdnf val66met variant. CD36 inhibition by salvionolic acid B (SAB) in diet-induced obese wild-type mice reduced visceral fat accumulation and improved insulin resistance. The benefit of SAB was aborted in CD36 knockout mice, showing the specificity of SAB. In addition, mice with the val66met variant in both alleles (BDNF M/M ) fed high-fat diet exhibited extreme obesity with increased CD36 gene and protein levels in macrophages. Chronic SAB treatment in BDNF M/M mice significantly decreased visceral fat accumulation and improved insulin resistance. Notably, the effect of SAB was greater in the extreme obese BDNF M/M mice compared to the wild-type mice. The study demonstrated a link between bdnf val66met and elevated CD36 expression, and suggested that CD36 inhibition may be a novel strategy to improve metabolic dysfunctions and to normalize risk factors for vascular diseases in the obese population.

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Section: M/mmentioning

confidence: 99%

Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant

Yang

Park

Cho

2018

Journal of Biological Chemistry

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“…However, Asians typically have a lower mean BMI with a higher prevalence of DM, compared with Caucasians at similar BMI values 20,21) . Therefore, other mechanisms, such as impaired insulin secretion, have been proposed to account for the development of DM 20,21,38,39) . In our study, the women in their analysis 7,15) .…”

Section: Utility Of Tg For Predicting Dmmentioning

confidence: 99%

“…Impaired insulin secretion, as well as the accumulation of visceral fat, a decrease in skeletal muscle mass and an increase in animal fat intake, may be related to the development of these diseases 20,21) . However, the association between TG and the incidence of DM in nonobese Japanese subjects is unclear.…”

Section: Introductionmentioning

confidence: 99%

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

Fujihara

Sugawara

Heianza

et al. 2014

JAT

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Aim: The levels of lipids, especially triglycerides (TG), and obesity are associated with diabetes mellitus (DM). Although typically measured in fasting individualsUtility of TG for Predicting Diabetes tions at baseline. Moreover, we excluded 19,191 men and 35,407 women who did not participate in the 1994 survey, thereby ensuring that subjects were followed up for at least one year. A total of 39,196 men and 87,980 women were followed up annually until the diagnosis of DM or the end of 2007. A fasting state was defined as not having had a meal for at least eight hours based on a self-reported questionnaire.

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“…Moreover, studies based on Western populations may not accurately represent patterns of body weight changes prior to diabetes diagnosis in Asians-a population in which BMI predicts outcomes differently [9][10][11] and in which at similar BMI levels the prevalence of diabetes has been shown to be higher compared to Caucasians. 12,13 This study examined long-term trajectories in BMI for individuals who did and did not develop diabetes in a retrospective cohort study, with participants aged 50+ from the Electronic supplementary material The online version of this article (doi:10.1007/s11606-016-3750-y) contains supplementary material, which is available to authorized users.…”

Section: Introductionmentioning

confidence: 99%

BMI Trajectories as a Harbinger of Pre-Diabetes or Underdiagnosed Diabetes: an 18-Year Retrospective Cohort Study in Taiwan

Chiu

et al. 2016

J GEN INTERN MED

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BACKGROUND: Although prior studies have examined BMI trajectories in Western populations, little is known regarding how BMI trajectories in Asian populations vary between adults with and without diabetes. OBJECTIVE: To examine how BMI trajectories vary between those developing and not developing diabetes over 18 years in an Asian cohort. DESIGN: Multilevel modeling was used to depict levels and rates of change in BMI for up to 18 years for participants with and without self-reported physiciandiagnosed diabetes. PARTICIPANTS: We used 14,490 data points available from repeated measurements of 3776 participants aged 50+ at baseline without diabetes from a nationally representative survey of the Taiwan Longitudinal Study on Aging (TLSA1989-2007). MAIN MEASURES: We defined development of diabetes as participants who first reported diabetes diagnoses in 2007 but had no diabetes diagnoses at baseline. We defined the reference group as those participants who reported the absence of diabetes at baseline and during the entire follow-up period. KEY RESULTS: When adjusted for time-varying comorbidities and behavioral factors, higher level and constant increases in BMI were present more than 6.5 years before self-reported diabetes diagnosis. The higher BMI level associating with the development of diabetes was especially evident in females. Within 6.5 years prior to self-reported diagnosis, however, a wider range of decreases in BMI occurred (β diabetes = 1.294, P = 0.0064; β diabetes*time = 0.150, P = 0.0327; β diabetes*time 2 = −0.008, P = 0.0065). The faster rate of increases in BMI followed by a greater decline was especially prominent in males and individuals with BMI ≧24. CONCLUSIONS: An unintentional decrease in BMI in sharp contrast to the gradually rising BMI preceding that time may be an alarm for undiagnosed diabetes or a precursor to developing diabetes.

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Understanding and Addressing Unique Needs of Diabetes in Asian Americans, Native Hawaiians, and Pacific Islanders

Cited by 106 publications

References 33 publications

Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant

Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-Val66Met variant

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

BMI Trajectories as a Harbinger of Pre-Diabetes or Underdiagnosed Diabetes: an 18-Year Retrospective Cohort Study in Taiwan

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