Understanding age-related diseases: report of the 2015 Ageing Summit

Lahousse, Lies; Moyse, Emmanuel; Krantic, Slavica; Brusselle, Guy

doi:10.1183/13993003.00837-2015

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…are likely to be involved in lung diseases such as COPD and idiopathic pulmonary fibrosis [65,66]. We need to better understand which mechanisms drive frailty in patients with COPD, as frailty reduces QoL [67] and increases hospitalisations, hospital readmissions [68] and inhospital mortality [69] in these patients.…”

Section: Epigenetic Alterations and Altered Intercellular Communicatimentioning

confidence: 99%

ERS International Congress 2020 Virtual: highlights from the Allied Respiratory Professionals Assembly

Smith

Thomas²,

Çalık-Kütükçü

et al. 2020

ERJ Open Res

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This article provides an overview of outstanding sessions that were (co)organised by the Allied Respiratory Professionals (ARP) Assembly during the European Respiratory Society (ERS) International Congress 2020, which this year assumed a virtual format. The content of the sessions was mainly targeted at ARP, including respiratory function technologists and scientists, physiotherapists and nurses, and is summarised in this highlights article. Short take-home messages related to spirometry and exercise testing are provided, highlighting the importance of quality control. In addition, the need for quality improvement in sleep interventions is underlined as it may enhance patient outcomes and the working capacity of healthcare services. The promising role of digital health in chronic disease management is discussed, with emphasis on the value of end-user participation in the development of these technologies. Evidence on the effectiveness of airway clearance techniques in chronic respiratory conditions is provided along with the rationale for its use and challenges to be addressed in future research. Furthermore, the importance of assessing, preventing and reversing frailty in respiratory patients is discussed, with a clear focus on exercise-based interventions. Research on the impact of disease-specific fear and anxiety on patient outcomes draws attention to the need for early assessment and intervention. Finally, advances in nursing care related to treatment adherence, self-management and patients’ perspective in asthma and COPD are provided, highlighting the need for patient engagement and shared decision making. This highlights article provides readers with valuable insight into the latest scientific data and emerging areas affecting clinical practice of ARP.

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Section: Epigenetic Alterations and Altered Intercellular Communicatimentioning

confidence: 99%

ERS International Congress 2020 Virtual: highlights from the Allied Respiratory Professionals Assembly

Smith

Thomas²,

Çalık-Kütükçü

et al. 2020

ERJ Open Res

View full text Add to dashboard Cite

show abstract

Age-dependent alterations in serum cytokines, peripheral blood mononuclear cell cytokine production, natural killer cell activity, and prostaglandin F2α

Lee

Kim

et al. 2017

Immunol Res

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This study aimed to determine age-dependent alterations in serum cytokines, peripheral blood mononuclear cell (PBMC) cytokine production, natural killer (NK) cell activity, and urinary 8-epi-prostaglandin F (PGF). Nine hundred eighty-seven healthy and nonobese subjects were divided into five age groups: 20-34 (group 1), 35-44 (group 2), 45-54 (group 3), 55-64 (group 4), and 65-80 (group 5) years of age. After adjusting for BMI, sex, and smoking and drinking status, serum interferon (IFN)-γ levels decreased in groups 3, 4, and 5 compared with those in groups 1 and 2. Production of IFN-γ by unstimulated PBMCs was lower in the older groups (groups 4 and 5) than in the younger groups (groups 1 and 3). Serum interleukin (IL)-12 was lower in group 5 than in groups 1 and 2. In contrast, both serum and PBMC IL-6 were higher in group 5 than in groups 1, 2, and 3. Urinary 8-epi-PGF increased in group 3 compared with that in group 1 and further increased in group 5. Multiple linear regression analysis revealed that serum IFN-γ levels were negatively affected by age, and NK cell activity at a ratio of E:T = 5:1 was positively affected by PBMC IFN-γ. This study shows the age-related reductions in serum and PBMC IFN-γ and serum IL-12 and age-related increases in serum and PBMC IL-6 and oxidative stress in healthy nonobese subjects. Additionally, circulating IL-6 levels may be a better marker of the chronic low-grade inflammatory activity associated with aging than systemic levels of high-sensitivity C-reactive protein, TNF-α, and IL-1β.

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Understanding age-related diseases: report of the 2015 Ageing Summit

Cited by 2 publications

References 30 publications

ERS International Congress 2020 Virtual: highlights from the Allied Respiratory Professionals Assembly

ERS International Congress 2020 Virtual: highlights from the Allied Respiratory Professionals Assembly

Age-dependent alterations in serum cytokines, peripheral blood mononuclear cell cytokine production, natural killer cell activity, and prostaglandin F2α

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