Understanding abnormal uterine artery Doppler waveforms: A novel computational model to explore potential causes within the utero-placental vasculature

Clark, Alys R.; James, Joanna L.; Stevenson, Gordon N.; Collins, Sally

doi:10.1016/j.placenta.2018.05.001

Cited by 51 publications

(61 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diameter of the arcuate artery in the model is 4 mm, while in Clark et al. (2018) it is 1–8 mm. (The effect of the vessel diameter was investigated.)…”

Section: Methodsmentioning

confidence: 75%

See 1 more Smart Citation

A data-driven model to study utero-ovarian blood flow physiology during pregnancy

Carson

Lewis

Rassi

et al. 2019

Biomech Model Mechanobiol

View full text Add to dashboard Cite

In this paper, we describe a mathematical model of the cardiovascular system in human pregnancy. An automated, closed-loop 1D–0D modelling framework was developed, and we demonstrate its efficacy in (1) reproducing measured multi-variate cardiovascular variables (pulse pressure, total peripheral resistance and cardiac output) and (2) providing automated estimates of variables that have not been measured (uterine arterial and venous blood flow, pulse wave velocity, pulsatility index). This is the first model capable of estimating volumetric blood flow to the uterus via the utero-ovarian communicating arteries. It is also the first model capable of capturing wave propagation phenomena in the utero-ovarian circulation, which are important for the accurate estimation of arterial stiffness in contemporary obstetric practice. The model will provide a basis for future studies aiming to elucidate the physiological mechanisms underlying the dynamic properties (changing shapes) of vascular flow waveforms that are observed with advancing gestation. This in turn will facilitate the development of methods for the earlier detection of pathologies that have an influence on vascular structure and behaviour. Electronic supplementary material The online version of this article (10.1007/s10237-019-01135-3) contains supplementary material, which is available to authorised users.

show abstract

“…The diameter of the arcuate artery in the model is 4 mm, while in Clark et al. (2018) it is 1–8 mm. (The effect of the vessel diameter was investigated.)…”

Section: Methodsmentioning

confidence: 75%

“…The model-estimated diameter of the uterine arteries is 2.47 mm at term, in Clark et al. (2018); Adamson et al. (1989), it is estimated to be 4 mm, and in Talbert (1995), it is estimated to be 2.8 mm (around 27 weeks gestation).…”

Section: Methodsmentioning

confidence: 97%

A data-driven model to study utero-ovarian blood flow physiology during pregnancy

Carson

Lewis

Rassi

et al. 2019

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…Measurements taken from micro-computed tomography scans in mice show that the radial arteries account for ~90% of total uteroplacental vascular resistance, 59 and computational modeling indicates the same is true for humans. 60 Hence, more attention should be paid to more proximal elements of the uteroplacental vascular tree in future . 6 1…”

Section: Placental Development Spiral Artery Remodeling and Early Omentioning

confidence: 99%

Pre-eclampsia: pathophysiology and clinical implications

Burton

Redman

Roberts

et al. 2019

BMJ

712

696

View full text Add to dashboard Cite

Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical presentation is highly variable but hypertension and proteinuria are usually seen. These systemic signs arise from soluble factors released from the placenta as a result of a response to stress of syncytiotrophoblast. There are two sub-types: early and late onset pre-eclampsia, with others almost certainly yet to be identified. Early onset pre-eclampsia arises owing to defective placentation, whilst late onset pre-eclampsia may center around interactions between normal senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease. The causes, placental and maternal, vary among individuals. Recent research has focused on placental-uterine interactions in early pregnancy. The aim now is to translate these findings into new ways to predict, prevent, and treat pre-eclampsia.

show abstract

“…Trophoblast plugs disintegrate completely near the end of the first trimester, and this is associated with significant onset of flow of oxygenated maternal blood into the intervillous space around 12–13 weeks of gestation [71–73]. This significant increase in flow is also thought to coincide with the completion of trophoblast-independent remodelling of the upstream radial arteries, which may act as the rate-limiting vessels regulating the volumetric flow of maternal blood into the intervillous space [71, 74–76]. As a result of trophoblast plugging, the placenta exists in a low oxygen environment for the majority of the first trimester, and this is thought to be key to promote placental development, vasculogenesis and angiogenesis.…”

Section: Development and Functional Properties Of The Early Chorionicmentioning

confidence: 99%

Human placenta and trophoblast development: key molecular mechanisms and model systems

Knöfler

Haider

Saleh

et al. 2019

Cell. Mol. Life Sci.

443

515

View full text Add to dashboard Cite

Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, pre eclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such as cardiovascular disease and type 2 diabetes. Despite their importance, the molecular mechanisms governing human placental formation and trophoblast cell lineage specification and differentiation have been poorly unravelled, mostly due to the lack of appropriate cellular model systems. However, over the past few years major progress has been made by establishing selfrenewing human trophoblast stem cells and 3dimensional organoids from human blastocysts and early placental tissues opening the path for detailed molecular investigations. Herein, we summarize the present knowledge about human placental development, its stem cells, progenitors and differentiated cell types in the trophoblast epithelium and the villous core. Anatomy of the early placenta, current model systems, and critical key regulatory factors and signalling cascades governing placentation will be elucidated. In this context, we will discuss the role of the developmental pathways Wingless and Notch, controlling trophoblast stemness/differentiation and formation of invasive trophoblast progenitors, respectively.

show abstract

Understanding abnormal uterine artery Doppler waveforms: A novel computational model to explore potential causes within the utero-placental vasculature

Abstract: This model suggests that to appropriately interpret UtA Doppler waveforms they must be considered to be reflecting changes in the entire system, rather than just the spiral arteries.

Cited by 51 publications

References 48 publications

A data-driven model to study utero-ovarian blood flow physiology during pregnancy

A data-driven model to study utero-ovarian blood flow physiology during pregnancy

Pre-eclampsia: pathophysiology and clinical implications

Human placenta and trophoblast development: key molecular mechanisms and model systems

Contact Info

Product

Resources

About