Undersizing mitral annuloplasty alters left ventricular mechanics in a swine model of ischemic mitral regurgitation

Xu, Dongyang; McBride, E. Anne; Kalra, Kanika; Wong, Keawepono; Guyton, Robert A.; Sarin, Eric L.; Padala, Muralidhar

doi:10.1016/j.jtcvs.2020.09.141

Cited by 15 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early work using large animals primarily centered around ischemic modeling, as coronary vasculature ligation or percutaneous ethanol injection provides straightforward mechanisms for inducing targeted infarction and subsequent ischemia (100)(101)(102)(103)(104). In studying ischemic valvular biomechanics, researchers have used these models to analyze a wide variety of phenomena such as ischemic remodeling of MV annular dynamics, surgical techniques, such as posterior leaflet augmentation and chordal cutting, the relationship between ischemic MR and ventricular remodeling, and the effects of annuloplasty ring selection and sizing for ischemic MR repair (102,103,(105)(106)(107)(108)(109)(110)(111)(112)(113). While studies such as these have shown the power of in vivo modeling capabilities, there are some key limitations with this line of research.…”

Section: In Vivo Modelingmentioning

confidence: 99%

Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation

Park

Zhu

Imbrie-Moore

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The field of heart valve biomechanics is a rapidly expanding, highly clinically relevant area of research. While most valvular pathologies are rooted in biomechanical changes, the technologies for studying these pathologies and identifying treatments have largely been limited. Nonetheless, significant advancements are underway to better understand the biomechanics of heart valves, pathologies, and interventional therapeutics, and these advancements have largely been driven by crucial in silico, ex vivo, and in vivo modeling technologies. These modalities represent cutting-edge abilities for generating novel insights regarding native, disease, and repair physiologies, and each has unique advantages and limitations for advancing study in this field. In particular, novel ex vivo modeling technologies represent an especially promising class of translatable research that leverages the advantages from both in silico and in vivo modeling to provide deep quantitative and qualitative insights on valvular biomechanics. The frontiers of this work are being discovered by innovative research groups that have used creative, interdisciplinary approaches toward recapitulating in vivo physiology, changing the landscape of clinical understanding and practice for cardiovascular surgery and medicine.

show abstract

Section: In Vivo Modelingmentioning

confidence: 99%

Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation

Park

Zhu

Imbrie-Moore

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…The objective in using the subvalvular correction procedure in association with RMA not only guarantees correction of the interpapillary muscle distance directly but allows monitoring of overcorrection through the annuloplasty, to develop mitral valve stenosis as complication [ 63 , 64 ].…”

Section: Subvalvular Proceduresmentioning

confidence: 99%

Exploring the Operative Strategy for Secondary Mitral Regurgitation: A Systematic Review

Nappi

Singh

Bellomo

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Background. Mitral valve disease surgery is an evolving field with multiple possible interventions. There is an increasing body of evidence regarding the optimal strategy in secondary mitral regurgitation where the pathology lies within the ventricle. We conducted a systematic review to identify the benefits and limitations of each surgical option. Methods. A systematic review of the literature was performed to identify pertinent randomized controlled trials (RCTs), propensity-matched observational series, and meta-analyses which were considered initially and followed by unmatched observational series using the MEDLINE, Ovid EMBASE, and Cochrane Library. Results. We identified 6 different strategies for treating secondary mitral valve regurgitation: mitral valve replacement, restrictive mitral annuloplasty, surgical revascularization (with and without mitral annuloplasty), subvalvular procedures (papillary muscle approximation, papillary muscle relocation, ring and string procedure), and procedures directly targeting the mitral valve (edge-to-edge repair and anterior leaflet enlargement) alongside transcatheter heart valve therapy. We also highlighted the role of left ventricular assist devices in the management of this condition. The benefits and limitations of each intervention are highlighted. Conclusion. There is currently no unanimous and shared strategy for the optimal treatment of patients with secondary IMR. The management of patients with secondary mitral regurgitation must be entrusted to a multidisciplinary Heart Team to ensure ideal intervention and patient matching for the best outcomes.

show abstract

“…Noack and colleagues reported that even for patients with poor ventricular ejection fraction of <30%, mitral valve repair could be safely performed [97]. Xu and colleagues reported that under-sizing annuloplasty was effective for eliminating MR [98]. Kainuma and colleagues reported favorable remodeling, decreased tethering distance and inter-papillary muscle distance during the follow-up period [99].…”

Section: Procedures On the Mitral Valvementioning

confidence: 99%

Cardiomyopathy: Recent Findings

Yamada¹,

Sugi²,

Nakajima³

et al. 2021

Cardiomyopathy - Disease of the Heart Muscle

View full text Add to dashboard Cite

In 1957, Wallace Brigden published an article on the Lancet, such as uncommon myocardial diseases: the non-coronary cardiomyopathy. In this article, he mentioned that “the term cardiomyopathy is used here to indicate isolated noncoronary myocardial disease.” Then “cardiomyopathy” has become a commonly used term in the cardiovascular field, and has been defined and classified by many researchers and academic societies. The basic concept of cardiomyopathy is a group of diseases with mechanical and/or electrophysiological dysfunction of the ventricles, and cardiomyopathy is distinguished with normal ischemic heart disease, valvular disease, and hypertensive heart disease. It can often cause heart failure and cardiac death. In this chapter, we describe the classification, details, and treatment of cardiomyopathy, and iPS cell from pathological myocardium.

show abstract

Undersizing mitral annuloplasty alters left ventricular mechanics in a swine model of ischemic mitral regurgitation

Cited by 15 publications

References 22 publications

Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation

Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation

Exploring the Operative Strategy for Secondary Mitral Regurgitation: A Systematic Review

Cardiomyopathy: Recent Findings

Contact Info

Product

Resources

About