Undernutrition – thirty years of the Regional Basic Diet: the legacy of Naíde Teodósio in different fields of knowledge

Pereira‐Acácio, Amaury; Ferreira, Bruna Soares; Silva-Pereira, Debora; Veloso-Santos, João P.M.; Alves-Bezerra, Danilo S.; Lopes, Jarlene A; Costa‐Sarmento, Glória; Lara, Lucienne S.; Vieira‐Filho, Leucio D.; Abadie-Guedes, Ricardo; Guedes, Rubem Carlos Araújo; Vieyra, Adalberto; Muzi‐Filho, Humberto

doi:10.1080/1028415x.2021.1915631

Cited by 7 publications

(10 citation statements)

References 86 publications

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“…This diet (Regional Basic Diet/RBD) mimics those used in vast impoverished regions of undeveloped countries, and also in pockets of poverty in big cities worldwide [5]. It has served for many years as a model for the study of many more pathologies in different organs and tissues [6]. Its protein content is low and of poor quality; lipids, vitamins, and minerals are also low.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-(3–4) normalizes the elevated arterial blood pressure and abnormal Na+/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors

et al. 2022

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We investigated the mechanisms by which chronic administration of a multideficient diet after weaning alters bodily Na+ handling, and culminates in high systolic blood pressure (SBP) at a juvenile age. From 28 to 92 days of age, weaned male Wistar rats were given a diet with low content and poor-quality protein, and low lipid, without vitamin supplementation, which mimics the diets consumed in impoverished regions worldwide. We measured food, energy and Na+ ingestion, together with urinary Na+ excretion, Na+ density (Na+ intake/energy intake), plasma Na+ concentration, SBP, and renal proximal tubule Na+-transporting ATPases. Undernourished rats aged 92 days had only one-third of the control body mass, lower plasma albumin, higher SBP, higher energy intake, and higher positive Na+ balance accompanied by decreased plasma Na+ concentration. Losartan or Ang-(3–4) normalized SBP, and the combination of the 2 substances induced an accentuated negative Na+ balance as a result of strong inhibition of Na+ ingestion. Na+ density in undernourished rats was higher than in control, irrespective of the treatment, and they had downregulated (Na++K+)ATPase and upregulated Na+-ATPase in proximal tubule cells, which returned to control levels after Losartan or Ang-(3–4). We conclude that Na+ density, not only Na+ ingestion, plays a central role in the pathophysiology of elevated SBP in chronically undernourished rats. The observations that Losartan and Ang-(3–4) normalized SBP together with negative Na+ balance give support to the proposal that Ang II⇒AT1R and Ang II⇒AT2R axes have opposite roles within the renin-angiotensin-aldosterone system of undernourished juvenile rats.

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Section: Introductionmentioning

confidence: 99%

Angiotensin-(3–4) normalizes the elevated arterial blood pressure and abnormal Na+/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors

et al. 2022

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“…We induced chronic undernutrition from weaning until a rat juvenile age [18] by offering ad libitum a multideficient diet, RBD, which mimics those widely used in countries and regions where undernutrition is endemic [10][11][12][13][14][15]. The content of proteins is very low (Table 1), and their quality is poor because their sources are beans and jerked beef.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic undernutrition is a pandemic growing nowadays, especially in low-income countries and impoverished areas of developed countries [9] where nearly 1 billion people are undernourished or facing a severe risk of undernutrition by eating a poor-quality diet. One widely used model of a multideficient diet for rats is that formulated based on the alimentary habits of people from several developing countries [10][11][12][13] the so-called Regional Basic Diet (RBD) [14] (Table 1) (for a recent review, see [15]). This pro-hypertensive diet [15][16][17] has brown beans, manioc flour, jerked meat, and sweet potatoes as the main ingredients.…”

Section: Introductionmentioning

confidence: 99%

“…One widely used model of a multideficient diet for rats is that formulated based on the alimentary habits of people from several developing countries [10][11][12][13] the so-called Regional Basic Diet (RBD) [14] (Table 1) (for a recent review, see [15]). This pro-hypertensive diet [15][16][17] has brown beans, manioc flour, jerked meat, and sweet potatoes as the main ingredients. [17].…”

Section: Introductionmentioning

confidence: 99%

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Undernutrition Modifies the Antihypertensive and Metabolic Responses of Rostafuroxin in Male Rats: Outcomes on Bodily Na<sup>+</sup> Handling and Renal Na<sup>+</sup>-transporting ATPases

Pereira‐Acácio¹,

Veloso-Santos²,

Costa‐Sarmento³

et al. 2023

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The aim of the present study was to investigate whether chronic undernutrition modifies the response to rostafuroxin in juvenile rats. Chronic undernutrition was induced in male rats using a multideficient diet known as Regional Basic Diet (RBD), mimicking alimentary habits in impoverished regions worldwide. Animals were given RBD – or a control/CTRL normal diet for rodents – from weaning to 90 days, and rostafuroxin (1 mg/kg body mass) or vehicle were orally administered during the last 30 days. Undernourished rats became hypertensive at 55–60 days of age (tail-cuff recording). During the last two days, the rats were hosted in metabolic cages to measure food/energy, water, Na+ ingestion, and urinary volume. Blood and kidneys were collected after euthanasia. Rostafuroxin increased food/energy and Na+ intake in CTRL and RBD rats but had opposite effects on Na+ balance (intake minus urinary excretion): negative in CTRL and positive in RBD. The drug normalized the decreased plasma Na+ concentration found in RBD rats, increased urinary volume in RBD but not in CTRL, and decreased and increased urinary Na+ concentration in the RBD and CTRL groups, respectively. Rostafuroxin decreased the ouabain-sensitive (Na++K+)ATPase and increased the ouabain-resistant, furosemide-sensitive Na+-ATPase from proximal tubule cells in both groups, and normalized the systolic blood pressure in RBD without effect in CTRL rats. We conclude that chronic undernutrition modifies the response of blood pressure, caloric metabolism, Na+ distribution in liquid compartments, mobilization of Na+ from non-osmotic compartments, Na+ and water balance, and activity of renal Na+-transporting ATPases to rostafuroxin.

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“…This is important due to conditions faced by hundreds of millions around the globe exposed to dietary inequalities. In Brazil, for example, a change has been noticed from an undernutrition status in impoverished areas from the Pernambuco State in the 1970-1980s and modeled as the Regional Basic Diet (RBD) to western-type high-fat foods nowadays (de Aquino et al, 2019;Jannuzzi et al, 2021). This nutritional transition from chronic consumption of hypoproteic (RBD) or high-fat diets may have consequences to the general health of the population ( de Aquino et al, 2019).…”

Section: Healthy Diet Supplements and Natural Productsmentioning

confidence: 99%

Quality of Life and a Surveillant Endocannabinoid System

et al. 2021

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The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders. Practice of regular physical and/or mind-body mindfulness and meditative activities have been shown to modulate endocannabinoid (eCB) levels, in addition to other players as brain-derived neurotrophic factor (BDNF). ECS is involved in pain, inflammation, metabolic and cardiovascular dysfunctions, general immune responses (asthma, allergy, and arthritis) and tumor expansion, both/either in the brain and/or in the periphery. The reason for such a vast impact is the fact that arachidonic acid, a precursor of eCBs, is present in every membrane cell of the body and on demand eCBs synthesis is regulated by electrical activity and calcium shifts. Novel lipid (lipoxins and resolvins) or peptide (hemopressin) players of the ECS also operate as regulators of physiological allostasis. Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPARγ might impact energy consumption, metabolism and cell death. To live a better life implies in a vigilant ECS, through healthy diet selection (based on a balanced omega-3 and -6 polyunsaturated fatty acids), weekly exercises and meditation therapy, all of which regulating eCBs levels, surrounded by a constructive social network. Cannabidiol, a diet supplement has been a major player with anti-inflammatory, anxiolytic, antidepressant, and antioxidant activities. Cognitive challenges and emotional intelligence might strengthen the ECS, which is built on a variety of synapses that modify human behavior. As therapeutically concerned, the ECS is essential for maintaining homeostasis and cannabinoids are promising tools to control innumerous targets.

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Undernutrition – thirty years of the Regional Basic Diet: the legacy of Naíde Teodósio in different fields of knowledge

Cited by 7 publications

References 86 publications

Angiotensin-(3–4) normalizes the elevated arterial blood pressure and abnormal Na+/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors

Angiotensin-(3–4) normalizes the elevated arterial blood pressure and abnormal Na+/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors

Undernutrition Modifies the Antihypertensive and Metabolic Responses of Rostafuroxin in Male Rats: Outcomes on Bodily Na<sup>+</sup> Handling and Renal Na<sup>+</sup>-transporting ATPases

Quality of Life and a Surveillant Endocannabinoid System

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