Undernutrition in the developing rat: effect upon myelination

Krigman, Martin R.; Hogan, Edward L.

doi:10.1016/0006-8993(76)90224-9

Cited by 129 publications

(50 citation statements)

References 31 publications

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“…Similar observa tions have been made in protein-malnourish ed animals [10] as well as in acute and chronic starved states [42]. As early as 1939, it was shown that the state of undernutri tion in growing rats leads to a delay in the eye opening [9], an observation subse quently confirmed by many workers [40,[56][57][58][59],…”

Section: Discussionsupporting

confidence: 67%

Effects of Undernutrition on the Visually Evoked Responses in Rats during Development

Puthuraya¹,

Nayar²,

Deo³

et al. 1980

Dev Neurosci

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Effects of postnatal undernutrition on the maturation of the visually evoked responses (VERs) were investigated in rats. The VERs were recorded from the surface of the visual cortex in response to a flash of light. In the normal animals as age advanced, various components of the response appeared, their latencies shortened with an augmentation of their amplitude. The ability to follow repetitive stimulation at higher frequencies was also found to increase with age. In the undernourished rats, the appearance of the first positive wave (P₁) was delayed, the latencies of P₁ and the first negative wave (N₁) were prolonged and the amplitudes were smaller as compared with their normal counterparts. These animals were unable to follow repetitive stimulation at higher frequencies. Though protein-calorie malnutrition retarded the ontogenetic maturation of the visual system, rehabilitation led to a significant ''catch up''.

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Section: Discussionsupporting

confidence: 67%

Effects of Undernutrition on the Visually Evoked Responses in Rats during Development

Puthuraya¹,

Nayar²,

Deo³

et al. 1980

Dev Neurosci

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“…According to Lai et al [24], the retarded myelination of the corpus callosum of undernourished rats must be related prim arily to the impaired maturation of oligoden drocytes; however, the reduced number of myelinated fibers and their poor degree of myelination might be additionally due to the reduced number of oligodendrocytes [25]. Some data agree with a normal timing of myelinogenesis in undernourishment, i.e., only the quantity of myelin deposited might be reduced [17,19,23,39]. However, other workers have reported changes in the normal timing of deposition of the different myelin components, such as proteins [41] or gangliosides [43].…”

Section: Discussionsupporting

confidence: 60%

Effects of Abnormal Thyroid State and Undernutrition on Carbonic Anhydrase and Oligodendroglia Development in the Rat Cerebellum

Clos¹,

Legrand²,

Limozin

et al. 1982

Dev Neurosci

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The developmental pattern of the isoenzyme II of carbonic anhydrase (CAII; EC 4.2.1.1), a specific marker for oligodendroglia, was studied in the cerebella of thyroid-deficient, thyroxine-treated and undernourished rats, and compared with that in normal animals. In the normal cerebellum, the total CAII content was low during the first 10 postnatal days and increased maximally between 20 and 25 days. At first, all the CAII was present in the soluble fraction; the membrane-bound form was detected only from the age of about 13 days. At 40 days, the soluble and particulate forms represented about 70 and 30%, respectively, of the total CAII. The amount of CAII (expressed per cerebellum or per milligram of total soluble proteins) was markedly decreased in undernourishment and still more in thyroid deficiency. Thyroxine treatment induced a very precocious but only transient increase in the CAII content of the cerebellum. At the end of the experimental period studied (40 days), the CAII content was reduced to the same extent in the thyroxine-treated and undernourished rats. While undernutrition did not modify the percentage of soluble and membrane-bound CAII, thyroxine treatment and thyroid deficiency, respectively, accelerated and delayed the appearance of the particulate form. At the age of 35 days, the total number of oligodendrocytes in the white matter of cerebellum around the primary fissure remained unaffected in the thyroid-deficient rats, but it was reduced by 20 and 30% in the thyroxine-treated and undernourished animals, respectively; the effect of undernourishment was irreversible. These biochemical and histological results were discussed taking into consideration the differential effects of abnormal thyroid state and undernourishment on myelinogenesis.

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“…Furthermore, both functions are reported to be sensitive to nutritive or hormonal deficiency [Krigman and Hogan, 1976]. Mourente and co-workers [1991] pointed out that in juvenile turbot and gilthead sea bream, DHA content in the brain increased remarkably with a DHA-rich diet, suggesting that juveniles at this stage might be undergoing axonal and dendritic growth, glial multiplication, myelination, and the development of enzyme systems.…”

Section: Discussionmentioning

confidence: 99%

Incorporation of Dietary Docosahexaenoic Acid into the Central Nervous System of the Yellowtail <i>Seriola quinqueradiata</i>

et al. 1999

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In order to show the involvement of docosahexaenoic acid (DHA) in the development of the central nervous system (CNS) in carangid fish, we conducted tracer experiments by feeding radioactive DHA to larval yellowtail (Seriola quinqueradiata). Artemia nauplii were enriched with ¹⁴C-labeled DHA and fed to larval yellowtail for eight or ten days. Autoradiography of frozen sections, using both electric imaging plates and X-ray sensitive film, clearly showed that DHA was incorporated into and retained in the brain, spinal cord, and eyes. The brain, eyes, gill raker, liver, guts, and other muscle and bone structures were dissected, and radioactivity was measured in each organ by liquid scintillation counter. The results of this study suggest the incorporation of DHA into the brain. Considering our previous results indicating that DHA-free fish cannot form schools, we conclude that the incorporation of DHA into the brain might be a critical factor in the ontogeny of schooling behavior.

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Undernutrition in the developing rat: effect upon myelination

Cited by 129 publications

References 31 publications

Effects of Undernutrition on the Visually Evoked Responses in Rats during Development

Effects of Undernutrition on the Visually Evoked Responses in Rats during Development

Effects of Abnormal Thyroid State and Undernutrition on Carbonic Anhydrase and Oligodendroglia Development in the Rat Cerebellum

Incorporation of Dietary Docosahexaenoic Acid into the Central Nervous System of the Yellowtail <i>Seriola quinqueradiata</i>

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