Abstract:The bacterium Deinococcus radiodurans survives exposure to more than 1.5 Mrad of ionizing irradiation or to extreme desiccation without lethality or mutagenesis. This tolerance derives from the ability of this organism to accurately mend numerous double-strand DNA breaks (DSBs), thus reassembling an intact genome from hundreds of fragments in a manner that restores chromosomal continuity. The only currently known mechanism that enables accurate repair of DSBs in bacteria is RecA-dependent homologous recombinat… Show more
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