Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats
Filip Tylš,
Čestmír Vejmola,
Vlastimil Koudelka
et al.
Abstract:IntroductionPsilocybin is one of the most extensively studied psychedelic drugs with a broad therapeutic potential. Despite the fact that its psychoactivity is mainly attributed to the agonism at 5-HT2A receptors, it has high binding affinity also to 5-HT2C and 5-HT1A receptors and indirectly modulates the dopaminergic system. Psilocybin and its active metabolite psilocin, as well as other serotonergic psychedelics, induce broadband desynchronization and disconnection in EEG in humans as well as in animals. Th… Show more
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