Abstract:Actomyosin (actin-myosin II complex)-mediated contractile forces are central to the generation of multifaceted uni-and multi-cellular material properties and dynamics such as cell division, migration, and tissue morphogenesis. In the present article, we summarize our recent researches addressing molecular mechanisms that ensure actomyosin-mediated directional cell-cell junction remodeling, either shortening or extension, driving cell rearrangement for epithelial morphogenesis. Genetic perturbation clarified tw… Show more
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