Underlying mechanisms of mindfulness meditation: Genomics, circuits, and networks

Gu, Yingqi; Zhu, Yi

doi:10.5498/wjp.v12.i9.1141

Cited by 4 publications

(4 citation statements)

References 102 publications

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“…It seems that this kind of intervention may engage top-down regulation from the prefrontal cortex and ACC to inhibit maladaptive pain signaling. Like OMT, mindfulness techniques regulate the sympathetic-parasympathetic balance, normalizing the HPA and the cardiovascular and immune systems [109,110].…”

Section: Psychological Approachesmentioning

confidence: 99%

Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain

Bonanno,

Papa,

Cerasa

et al. 2024

Medicina

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Chronic stress and chronic pain share neuro-anatomical, endocrinological, and biological features. However, stress prepares the body for challenging situations or mitigates tissue damage, while pain is an unpleasant sensation due to nociceptive receptor stimulation. When pain is chronic, it might lead to an allostatic overload in the body and brain due to the chronic dysregulation of the physiological systems that are normally involved in adapting to environmental challenges. Managing stress and chronic pain (CP) in neurorehabilitation presents a significant challenge for healthcare professionals and researchers, as there is no definitive and effective solution for these issues. Patients suffering from neurological disorders often complain of CP, which significantly reduces their quality of life. The aim of this narrative review is to examine the correlation between stress and pain and their potential negative impact on the rehabilitation process. Moreover, we described the most relevant interventions used to manage stress and pain in the neurological population. In conclusion, this review sheds light on the connection between chronic stress and chronic pain and their impact on the neurorehabilitation pathway. Our results emphasize the need for tailored rehabilitation protocols to effectively manage pain, improve treatment adherence, and ensure comprehensive patient care.

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Section: Psychological Approachesmentioning

confidence: 99%

Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain

Bonanno,

Papa,

Cerasa

et al. 2024

Medicina

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“…Breathwork, included in many mindfulness meditation practices, includes slow breathing practices. This practice increases links between the parasympathetic and central nervous systems, which produces higher order cognitive control and mental flexibility [ 28 ]. During times of physiological stress response activation, therefore, the neural centers responsible for interpreting and reducing stress responses are also activated, resulting in stress reduction.…”

Section: Reviewmentioning

confidence: 99%

“…One negative effect of stress is the upregulation of inflammatory biomarkers. Mindfulness meditation may counteract the negative inflammatory effects of stress by changing gene expression over time to downregulate inflammatory proteins [ 28 ]. Mindfulness-based interventions also exert effects on stress responses via neural pathways in the brain.…”

Section: Reviewmentioning

confidence: 99%

Healthcare Workers' Well-Being: A Systematic Review of Positive Psychology Interventions

Townsley¹,

Li-Wang²,

Katta³

2023

Cureus

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Given persistent occupational stressors and multiple challenges in the delivery of healthcare, there is an increased focus on the well-being of healthcare workers. Responding to these challenges will require a multipronged approach, focusing on system level, organization, and individual actions. Positive psychology interventions (PPIs) represent a promising area for individual action. This systematic review indicates that PPI, delivered via many methods, holds promise for improving the well-being of healthcare workers, although there is a clear need for additional randomized controlled trials utilizing defined and standardized outcome measures. In this review, the most commonly evaluated PPIs were mindfulness-based or gratitudebased interventions. These were delivered via different methods, with many administered in the workplace and commonly in the form of courses ranging from two days to eight weeks. Researchers documented measurable improvements in multiple studied outcomes, noting reductions in symptoms of depression, anxiety, burnout, and stress. Some interventions increased well-being, job and life satisfaction, selfcompassion, relaxation, and resilience. Most studies emphasized that these are simple, accessible, low-cost interventions. Limitations included some nonrandomized or quasi-experimental designs, alongside generally small sample sizes and varying methods of intervention delivery. Another concern is the lack of standardized outcome assessments and long-term follow-up data. As almost all studies included were performed before the pandemic, further research will be required post-pandemic. Overall, however, PPI shows promise as one arm of a multipronged approach to improving the well-being of healthcare workers.

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“…Accumulating evidence indicates mindfulness impacts pain modulatory neurotransmitters including endogenous opioids, endocannabinoids, serotonin, and dopamine [ 193 ]. Genomics and proteomics studies indicate mindfulness reduces expression of inflammatory genes and proteins, mitigating peripheral and central sensitization [ 194 ].…”

Section: Types Of Ninptmentioning

confidence: 99%

Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

Shi,

2023

BMC Med

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Background Chronic pain conditions impose significant burdens worldwide. Pharmacological treatments like opioids have limitations. Non-invasive non-pharmacological therapies (NINPT) encompass diverse interventions including physical, psychological, complementary and alternative approaches, and other innovative techniques that provide analgesic options for chronic pain without medications. Main body This review elucidates the mechanisms of major NINPT modalities and synthesizes evidence for their clinical potential across chronic pain populations. NINPT leverages peripheral, spinal, and supraspinal mechanisms to restore normal pain processing and limit central sensitization. However, heterogeneity in treatment protocols and individual responses warrants optimization through precision medicine approaches. Conclusion Future adoption of NINPT requires addressing limitations in standardization and accessibility as well as synergistic combination with emerging therapies. Overall, this review highlights the promise of NINPT as a valuable complementary option ready for integration into contemporary pain medicine paradigms to improve patient care and outcomes.

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Underlying mechanisms of mindfulness meditation: Genomics, circuits, and networks

Cited by 4 publications

References 102 publications

Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain

Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain

Healthcare Workers' Well-Being: A Systematic Review of Positive Psychology Interventions

Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

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