Underlying mechanism of hemodynamics and intracranial aneurysm

Abstract

In modern society, subarachnoid hemorrhage, mostly caused by intracranial aneurysm rupture, is accompanied by high disability and mortality rate, which has become a major threat to human health. Till now, the etiology of intracranial aneurysm has not been entirely clarified. In recent years, more and more studies focus on the relationship between hemodynamics and intracranial aneurysm. Under the physiological condition, the mechanical force produced by the stable blood flow in the blood vessels keeps balance with the structure of the blood vessels. When the blood vessels are stimulated by the continuous abnormal blood flow, the functional structure of the blood vessels changes, which becomes the pathophysiological basis of the inflammation and atherosclerosis of the blood vessels and further promotes the occurrence and development of the intracranial aneurysm. This review will focus on the relationship between hemodynamics and intracranial aneurysms, will discuss the mechanism of occurrence and development of intracranial aneurysms, and will provide a new perspective for the research and treatment of intracranial aneurysms.

Dysregulated Hemostasis and Immunothrombosis in Cerebral Cavernous Malformations

“…A tortuous vascular phenotype is present in CCM lesions, which is driven by the shape of the characteristic mulberry-like vessels. It is known that the pathological dilations found in aneurysms can lead to turbulent, low-blood flow which promotes endothelial dysfunction, inflammation and even ruptures [ 69 ]. Likewise, CCM lesions are prone to blood stasis and disturbed flow due to their irregular shape.…”

miR-139-5p Suppresses Proliferation and Angiogenesis of Intracranial Aneurysm via FGB

“…Intracranial aneurysm (IA) is a common cerebrovascular disease [ 1 ]. It has high morbidity and mortality in patients aged 40–60 years [ 1 ].…”

“…Intracranial aneurysm (IA) is a common cerebrovascular disease [ 1 ]. It has high morbidity and mortality in patients aged 40–60 years [ 1 ]. It is characterized by abnormal swelling of cerebral arteries [ 2 ].…”

Hemodynamic Parameters in the Parent Arteries of Unruptured Intracranial Aneurysms Depend on Aneurysm Size and Are Different Compared to Contralateral Arteries: A 7 Tesla 4D Flow MRI Study

“…[6][7][8] It is known that variations in the configuration of the CoW, with concomitant hemodynamic variations, are related to aneurysmal development. 9 Novel imaging techniques such as four-dimensional (4D) flow at 7 Tesla (7 T) magnetic resonance imaging (MRI) enable accurate and reproducible measurement and quantification of blood flow and the resulting WSS, mean velocity, velocity pulsatility index (vPI), and the arterial distensibility of the intracranial vessels. 10,11 This study aimed to compare the hemodynamics parameters in the parent artery of the UIA to the corresponding contralateral artery without an UIA, using 7 T 4D flow MRI.…”

“…Several studies related intra‐aneurysmal hemodynamics to aneurysmal size and growth, in which the most established hemodynamic parameters associated with UIA were complex flows, concentrated areas of high WSS, or frictional forces 6–8 . It is known that variations in the configuration of the CoW, with concomitant hemodynamic variations, are related to aneurysmal development 9 . Novel imaging techniques such as four‐dimensional (4D) flow at 7 Tesla (7 T) magnetic resonance imaging (MRI) enable accurate and reproducible measurement and quantification of blood flow and the resulting WSS, mean velocity, velocity pulsatility index (vPI), and the arterial distensibility of the intracranial vessels 10,11 …”