Underlying Autoimmune Activation Rendering Paradoxical Non-Linear Relationship between Biomarkers and Cardiometabolic Risk

Onat, Altan; Kaya, Adnan

doi:10.4172/2155-9899.1000391

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…The observation in the study from Israel that patients with chronic renal disease and a history of stroke presented further independent predictors of all-cause mortality supports this interpretation, insofar as such outcomes - and incident subclinical hypothyroidism - have been predicted by low HbA 1c levels [8,9] which likely represent an underlying autoimmune process [8]. Other than plasma HbA 1c , a number of proteins or polypeptides have been epidemiologically documented to be involved in the proinflammatory state and autoimmune activation (for details, see the brief review by Onat et al [11]).…”

mentioning

confidence: 73%

Modulators of J-Shaped Association of HbA<sub>1c</sub> Levels with Mortality in Adults

Altay

Onat²,

Kaya³

et al. 2016

Cardiology

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mentioning

confidence: 73%

Modulators of J-Shaped Association of HbA<sub>1c</sub> Levels with Mortality in Adults

Altay

Onat²,

Kaya³

et al. 2016

Cardiology

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“…Our findings hint potentially to a sex‐specificity in the use of antidepressants in the context of developing diabetes. Turkish women who are susceptible to enhanced inflammation and autoimmune activation more than men (Onat and Can, ; Onat et al , 2016) support such a potential link, in view of reports that prolonged use of another group of drugs has been repeatedly documented to predict incident diabetes (Sattar et al , ; Culver et al , ; Wang et al , ). Interestingly, in experiments on rats, simvastatin administration exerted antidepressant‐like effects in diabetes‐induced rat groups, mediated by decreasing corticosterone levels, as compared with the control group (El Batsh, ).…”

Section: Discussionmentioning

confidence: 99%

Sex‐dependent independent prediction of incident diabetes by depressive symptoms

Akbaş-Şimşek

Onat

Kaya

et al. 2016

Int J Geriat Psychiatry

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“…Non-linearity of a biomarker in association with an outcome is often related to plasma proteins sustaining epitope damage due to oxidative stress, which has the capacity to impact on the risk of cardiometabolic disease. 20 It is notable that the Helsinki Birth Cohort study of 967 women showed a significant inverse association between birth length and subsequent development of CHD, 21 suggesting that the interplay of oxidised Lp(a) and a proinflammatory state with both body height and impact on incident CHD.…”

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confidence: 99%

Breastfeeding: A bystander marker of improvement in multiparity-induced cardiometabolic disease risk?

Onat

2016

Eur J Prev Cardiolog

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Metabolic and cardiovascular changes in pregnancyThe cardiovascular system undergoes notable structural and haemodynamic changes during the course of pregnancy, such that some call pregnancy nature's stress test.1 Contrary to previous generally held belief, some recent studies demonstrated a progressive increase in blood pressure (BP) throughout gestation in women who were overweight before pregnancy.2 In a population-based cohort study, obese and overweight women had a higher BP throughout pregnancy.3 Substantial ethnic differences exist in the BP levels that are observed during pregnancy and the risk of gestational hypertension. 4 Childbearing was associated with incidence of the metabolic syndrome (MetS) among women with gestational diabetes mellitus (DM) and, after controlling for preconception body mass index (BMI) and MetS components, in primi-and multiparous women without gestational DM as well. 5Associations between higher parity and prevalence of DM have been mixed, and even an increased risk of DM with nulliparity was reported among Native American women.6 Multiparity is associated with coronary heart disease (CHD), showing a a J-shaped relationship with higher risk for nulliparous women. 7,8 Decreases in serum creatinine and uric acid values have been attributed to rises in glomerular filtration rates by the end of the first trimester. 9 Higher baseline levels of a measure of aortic stiffness have been observed in multiparous compared with nulliparous women.1 Both multiparity and nulliparity have been associated with higher insulin levels many years after childbearing.10 Viewed from the perspective of correlates of lipoprotein(a) (Lp(a)), 11 gestation may reflect underlying 'reduced' serum Lp(a) assays and autoimmune activation. Influence of lactationA prospective study on a relatively small sample examined the relationship between lactation and changes in maternal metabolic risk factors and found a tendency towards improved serum high-density lipoprotein cholesterol and fasting insulin, 12 changes that are potentially consistent with underlying rises in Lp(a) levels.11 Longer duration of lactation was associated with a lower incidence of the MetS years after delivery and after weaning among women with non-gestational DM, as well as with gestational DM pregnancies. Lactation may ameliorate the increased risk of the MetS that is associated with higher parity.5 Data from the Coronary Artery Risk Development in Young Adults (CARDIA) study provided evidence that lactation may have lasting favourable effects on the risk of the MetS among women, regardless of a history of gestational DM. 13 However, this protection seemed to be absent in overweight women and black women without gestational DM, suggesting a possible interaction with adiposity, given the generally inverse association between BMI and Lp(a) and the existence of two-fold higher Lp(a) levels in black compared with white women. 11In a cohort of 177,749 Korean premenopausal women, the risk of the development of hypertension was significantly reduce...

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Underlying Autoimmune Activation Rendering Paradoxical Non-Linear Relationship between Biomarkers and Cardiometabolic Risk

Cited by 3 publications

References 30 publications

Modulators of J-Shaped Association of HbA<sub>1c</sub> Levels with Mortality in Adults

Modulators of J-Shaped Association of HbA<sub>1c</sub> Levels with Mortality in Adults

Sex‐dependent independent prediction of incident diabetes by depressive symptoms

Breastfeeding: A bystander marker of improvement in multiparity-induced cardiometabolic disease risk?

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