Underground railway particulate matter and susceptibility to pneumococcal infection

Miyashita, Lisa; Shears, Rebecca K.; Foley, Gary; Semple, Sean; Kadioglu, Aras; Grigg, Jonathan

doi:10.1016/j.ebiom.2022.104063

Cited by 9 publications

(3 citation statements)

References 22 publications

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“…It has been demonstrated that the antimicrobial activities of cathelicidin, including antibacterial and antiviral actions, are substantially suppressed by exposure to carbon particles (Findlay et al., 2017 ). Studies in vitro showed that traffic‐related particles could enhance pneumococcal adhesion to the airway via up‐regulated expressions of platelet‐activating factor receptor (Miyashita et al., 2022 ). A recent clinical study showed that ambient combustion‐related particles (e.g., BC and Delta‐C) were associated with alterations in the transcriptomic of respiratory infection‐related immune responses in patients hospitalized with ARI (Croft et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Ambient Anthropogenic Carbons and Pediatric Respiratory Infections: A Case‐Crossover Analysis in the Megacity Beijing

Song

et al. 2023

GeoHealth

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Carbon loading in airway cells has shown to worsen function of antimicrobial peptides, permitting increased survival of pathogens in the respiratory tract; however, data on the impacts of carbon particles on childhood acute respiratory infection (ARI) is limited. We assembled daily health data on outpatient visits for ARI (bronchitis, pneumonia, and total upper respiratory infection [TURI]) in children aged 0–14 years between 2015 and 2019 in Beijing, China. Anthropogenic carbons, including black carbon (BC) and its emission sources, and wood smoke particles (delta carbon, ultra‐violet absorbing particulate matter, and brown carbon) were continuously monitored. Using a time‐stratified case‐crossover approach, conditional logistic regression was performed to derive risk estimates for each outcome. A total of 856,899 children were included, and a wide range of daily carbon particle concentrations was observed, with large variations for BC (0.36–20.44) and delta carbon (0.48–57.66 μg/m3). Exposure to these particles were independently associated with ARI, with nearly linear exposure‐response relationships. Interquartile range increases in concentrations of BC and delta carbon over prior 0–8 days, we observed elevation of the odd ratio of bronchitis by 1.201 (95% confidence interval, 1.180, 1.221) and 1.048 (95% CI, 1.039, 1.057), respectively. Stronger association was observed for BC from traffic sources, which increased the odd ratio of bronchitis by 1.298 (95% CI, 1.273, 1.324). Carbon particles were also associated with elevated risks of pneumonia and TURI, and subgroup analyses indicated greater risks among children older than 6 years. Our findings suggested that anthropogenic carbons in metropolitan areas may pose a significant threat to clinical manifestations of respiratory infections in vulnerable populations.

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Section: Discussionmentioning

confidence: 99%

Ambient Anthropogenic Carbons and Pediatric Respiratory Infections: A Case‐Crossover Analysis in the Megacity Beijing

Song

et al. 2023

GeoHealth

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“…This potentially involves TLRs [14], as indicated in patient cohorts [31] and cell-based in vitro studies [8,32]. A549 and human primary epithelial cells exposed to PM showed increased Streptococcus pneumoniae bacterial adhesion, a process involving the GPCR for platelet-activating factor, a mediator known to drive pathogen phagocytosis and inflammation [33] (Figure 2). Also, PM has been suggested to act as a pathogen carrier, possibly serving as an infection-spreading mechanism [32].…”

Section: Glossarymentioning

confidence: 93%

Unravelling the signaling power of pollutants

Manzano-Covarrubias,

Yan,

Luu

et al. 2023

Trends in Pharmacological Sciences

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“…Moreover, particulate matter has the ability to hone in on the placenta, causing threatening effects in utero [ 54 , 60 ]. Studies have revealed that exposure to such particulate matter also increases susceptibility to infection [ 61 , 62 ]. For instance, exposure to particulate matter increases angiotensin-converting enzyme 2 (ACE2) receptor expression in vero-E6 cells and enhances their susceptibility to SARS-CoV-2 [ 61 ].…”

Section: Increasing the Visibility Of Translational Science At The Er...mentioning

confidence: 99%

The importance of translational science within the respiratory field

Meiners,

Reynaert,

Matthaiou

et al. 2024

Breathe

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The Translational Science Working Group at the European Respiratory Society (ERS) aims to bridge the gap between basic and clinical science by providing a platform where scientists, clinicians and experts in the respiratory field can actively shape translational research. For the 2023 Congress, dedicated translational science sessions were created and sessions of interest to many assemblies from the clinical and the scientific point of view were tagged as translational sessions, attracting clinical and scientific experts to the same room to discuss relevant topics and strengthening translational efforts among all ERS assemblies.

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Underground railway particulate matter and susceptibility to pneumococcal infection

Cited by 9 publications

References 22 publications

Ambient Anthropogenic Carbons and Pediatric Respiratory Infections: A Case‐Crossover Analysis in the Megacity Beijing

Ambient Anthropogenic Carbons and Pediatric Respiratory Infections: A Case‐Crossover Analysis in the Megacity Beijing

Unravelling the signaling power of pollutants

The importance of translational science within the respiratory field

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