Underestimation of Trisomy 18 and 13 Syndromes in Vital Statistics from Inadequate Death Certificates

Reply to the Letter to the Editor “Underestimation of Trisomy 18 and 13 Syndromes in Vital Statistics from Inadequate Death Certificates”

“…Their study team performed a Child Death Review in Shiga Prefecture, Japan, for victims younger than 18 years between 2015 and 2020 and examined 7 T18 cases and 5 trisomy 13 syndrome (T13) cases. The authors indicated that in some cases, death certificates had not been correctly generated according to the manual, which led to the underestimation of the number of T18 and T13 patients included in vital statistics [1]. Their findings are consistent with our study result for the data in 2014–2016.…”

“…We read with great interest the Letter from Takashima and Hitosugi [1] to the Editor. Their study team performed a Child Death Review in Shiga Prefecture, Japan, for victims younger than 18 years between 2015 and 2020 and examined 7 T18 cases and 5 trisomy 13 syndrome (T13) cases.…”

“…Thank you for the opportunity to reply to the Letter to the Editor by Dr. Takashima and Prof. Hitosugi [1]. We appreciate their comments regarding our article [2].…”