Underestimated Risks of Microplastics on the Environmental Spread of Antibiotic Resistance Genes

Wu, Jing; Liu, Dong-Feng; Wu, Jie; He, Rui; Cheng, Zhou‐Hua; Li, Wen‐Wei

doi:10.1021/acsestwater.3c00209

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…These processes may occur simultaneously during the transfer of antibiotic-resistance genes in the presence of MPs, and determining their specific contributions will require targeted future research. Interestingly, polyvinyl alcohol has been shown to decrease the diversity of antibiotic-resistance genes in estuary sediment, while polyvinyl chloride had minimal impact, yet both increased antibiotic-resistance gene diversity in river water [95]. Further investigation is needed to clarify these observations.…”

Section: 2antibiotic Resistancementioning

confidence: 99%

“…This suggests that MPs may enhance the exchange of antibiotic-resistance genes among different microbial species, potentially accelerating the spread of antibiotic resistance in water ecosystems. Polyvinyl alcohol, when present in river water, has been observed to raise both the variety and number of antibiotic-resistance genes, which may contribute to the spread of antibioticresistant bacteria [95]. Bacterial membrane permeability can increase upon direct interactions with MPs, which aids in the uptake and transfer of antibiotic-resistance genes [96].…”

Section: 2antibiotic Resistancementioning

confidence: 99%

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Microplastics and Antibiotics in Aquatic Environments: A Review of Their Interactions and Ecotoxicological Implications

Tang

2024

Trop. Aqua. Soil Pollut.

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Microplastics and antibiotics are two significant emerging pollutants found together in water bodies, raising concerns about their mutual effects. This review delves into how microplastics and antibiotics interact in aqueous environments and the ecotoxicological implications of such interactions, particularly the bioavailability of antibiotics and the prevalence of antibiotic-resistance genes. It outlines that antibiotics attach to microplastics primarily through hydrophobic, hydrogen-bonding, and electrostatic interactions. Other bonds, comprising halogen bonding, cation−π interaction, and negative charge-assisted hydrogen bonds, may also be involved to better explain antibiotic adsorption patterns. The adsorption of antibiotics to microplastics often follows the pseudo-second-order kinetic model and in some instances, the pseudo-first-order kinetic model. The common adsorption isotherms governing this interaction are the linear and Freundlich models. Microplastics may increase the biodegradation of adsorbed antibiotics due to the presence of antibiotic-degrading bacteria in the biofilms. They could also hamper direct photodegradation but facilitate indirect photodegradation of adsorbed antibiotics. However, their photodegradative effect remains inconclusive. Microplastics and antibiotics exhibit significant toxicity to algae, while their effects on fish and daphnia are less noticeable, suggesting that their combination does not pose an immediate threat to the well-being and proliferation of larger aquatic organisms. In some instances, microplastics reduce the deleterious effects of antibiotics on aquatic life. Microplastics serve as catalysts for gene transfer, enhancing the propagation of antibiotic-resistance genes in these ecosystems. This review underscores the importance of understanding the regulatory mechanisms of microplastics on antibiotic-resistance gene diversity, particularly at the gene expression level.

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Section: 2antibiotic Resistancementioning

confidence: 99%

Section: 2antibiotic Resistancementioning

confidence: 99%

Microplastics and Antibiotics in Aquatic Environments: A Review of Their Interactions and Ecotoxicological Implications

Tang

2024

Trop. Aqua. Soil Pollut.

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“…Plastics are widely used in industry, food, and healthcare and have caused the spread of plastic waste around the world . It is estimated that 6300 million tons of plastic waste has been generated, with 79% of this waste ending up in landfills or accumulating in the environment; , ∼50% of plastic is single-use disposable material .…”

mentioning

confidence: 99%

Global Perspective on the Impact of Plastic Waste as a Source of Microplastics and Per- and Polyfluoroalkyl Substances in the Environment

Sangkham

2023

ACS EST Water

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Are microplastics in aquaculture an undeniable driver in accelerating the spread of antibiotic resistance genes?

Jin,

Zhang,

Zhao

et al. 2023

Environ Sci Pollut Res

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Underestimated Risks of Microplastics on the Environmental Spread of Antibiotic Resistance Genes

Cited by 6 publications

References 23 publications

Microplastics and Antibiotics in Aquatic Environments: A Review of Their Interactions and Ecotoxicological Implications

Microplastics and Antibiotics in Aquatic Environments: A Review of Their Interactions and Ecotoxicological Implications

Global Perspective on the Impact of Plastic Waste as a Source of Microplastics and Per- and Polyfluoroalkyl Substances in the Environment

Are microplastics in aquaculture an undeniable driver in accelerating the spread of antibiotic resistance genes?

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