Underestimated microbial infection of resorbable membranes on guided regeneration

Abdo, Victoria L.; Suárez, Lina J; Paula, Lucca Gomes de; Costa, Raphael Cavalcante; Shibli, Jamil Awad; Feres, Magda; Barão, Valentim A. R.; Bertolini, Martinna; Souza, João Gabriel Silva

doi:10.1016/j.colsurfb.2023.113318

Cited by 14 publications

(9 citation statements)

References 157 publications

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“…The adhesion and growth of various oral bacteria directly influence the therapeutic efficacy of periodontitis [ 13 ]. Therefore, achieving antimicrobial functionality is a pivotal factor in the application of medical materials during the treatment for periodontitis.…”

Section: Resultsmentioning

confidence: 99%

“…Nowadays, multiple biomaterials have been developed for the treatment of periodontitis, including antibacterial agents, ROS-scavenging and Immunomodulatory biomaterials [ 10 , 11 ]. However, most biomaterials and traditional treatment approaches performed single function, failing to meet the multifunctional requirements for bone regeneration in periodontitis for infection caused by the colonization of pathogens at the defect site is one of the main causes of GBR failure as reported [ 12 , 13 ], thus, there is an urgent need for an effective treatment modality for treating periodontitis.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic hydrogel–metal–organic framework system promotes bone regeneration in periodontitis through controlled drug delivery

Luo,

Yang,

et al. 2024

J Nanobiotechnol

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Periodontitis is a prevalent chronic inflammatory disease, which leads to gradual degradation of alveolar bone. The challenges persist in achieving effective alveolar bone repair due to the unique bacterial microenvironment’s impact on immune responses. This study explores a novel approach utilizing Metal–Organic Frameworks (MOFs) (comprising magnesium and gallic acid) for promoting bone regeneration in periodontitis, which focuses on the physiological roles of magnesium ions in bone repair and gallic acid's antioxidant and immunomodulatory properties. However, the dynamic oral environment and irregular periodontal pockets pose challenges for sustained drug delivery. A smart responsive hydrogel system, integrating Carboxymethyl Chitosan (CMCS), Dextran (DEX) and 4-formylphenylboronic acid (4-FPBA) was designed to address this problem. The injectable self-healing hydrogel forms a dual-crosslinked network, incorporating the MOF and rendering its on-demand release sensitive to reactive oxygen species (ROS) levels and pH levels of periodontitis. We seek to analyze the hydrogel’s synergistic effects with MOFs in antibacterial functions, immunomodulation and promotion of bone regeneration in periodontitis. In vivo and in vitro experiment validated the system's efficacy in inhibiting inflammation-related genes and proteins expression to foster periodontal bone regeneration. This dynamic hydrogel system with MOFs, shows promise as a potential therapeutic avenue for addressing the challenges in bone regeneration in periodontitis. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamic hydrogel–metal–organic framework system promotes bone regeneration in periodontitis through controlled drug delivery

Luo,

Yang,

et al. 2024

J Nanobiotechnol

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“…In recent years, guided regeneration therapy has gained more interest because it is based on the idea that cells with regenerative capabilities can aid in the regeneration of lost tissue [ 80 ]. For periodontal disease, two surgical approaches are used: GTR and GBR.…”

Section: The Innovation Of Tissue Engineering and Regenerative Medici...mentioning

confidence: 99%

Recent Advances in Functionalized Electrospun Membranes for Periodontal Regeneration

Epicoco,

Pellegrino,

Madaghiele

et al. 2023

Pharmaceutics

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Periodontitis is a global, multifaceted, chronic inflammatory disease caused by bacterial microorganisms and an exaggerated host immune response that not only leads to the destruction of the periodontal apparatus but may also aggravate or promote the development of other systemic diseases. The periodontium is composed of four different tissues (alveolar bone, cementum, gingiva, and periodontal ligament) and various non-surgical and surgical therapies have been used to restore its normal function. However, due to the etiology of the disease and the heterogeneous nature of the periodontium components, complete regeneration is still a challenge. In this context, guided tissue/bone regeneration strategies in the field of tissue engineering and regenerative medicine have gained more and more interest, having as a goal the complete restoration of the periodontium and its functions. In particular, the use of electrospun nanofibrous scaffolds has emerged as an effective strategy to achieve this goal due to their ability to mimic the extracellular matrix and simultaneously exert antimicrobial, anti-inflammatory and regenerative activities. This review provides an overview of periodontal regeneration using electrospun membranes, highlighting the use of these nanofibrous scaffolds as delivery systems for bioactive molecules and drugs and their functionalization to promote periodontal regeneration.

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“…6 The resorbable collagen membrane is considered the standard reference for GBR because of its good biocompatibility and biodegradability. 7 However, the insufficient mechanical proper-ties and fast degradation induced by proteases limit their clinical application, especially for vertical augmentation. 8 In addition, almost all membrane products only act as a passive barrier, lacking bioactive functions, such as osteogenesis and anti-infection.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, the occurrence of infection during GBR treatment recovery reduces the volume of the regenerated bone from 90–100 to 42–62% . The resorbable collagen membrane is considered the standard reference for GBR because of its good biocompatibility and biodegradability . However, the insufficient mechanical properties and fast degradation induced by proteases limit their clinical application, especially for vertical augmentation .…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Magnesium and Zinc Metallic Particles in PLGA Bi-layered Membranes with Sequential Ion Release for Guided Bone Regeneration

Tang

Bai

et al. 2023

ACS Biomater. Sci. Eng.

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Guided bone regeneration (GBR) membranes are commonly used for periodontal tissue regeneration. Due to the complications of existing GBR membranes, the design of bioactive membranes is still relevant. GBR membranes with an asymmetric structure can accommodate the functional requirements of different interfacial tissues. Here, poly(lactic acid-glycolic acid) (PLGA) was selected as the matrix for preparing a bi-layered membrane with both dense and porous structure. The dense layer for blocking soft tissues was incorporated with zinc (Zn) particles, while the porous layer for promoting bone regeneration was co-incorporated with magnesium (Mg) and Zn particles. Mg/Zn-embedded PLGA membranes exhibited 166% higher mechanical strength in comparison with pure PLGA membranes and showed suitable degradation properties with a sequential ion release behavior of Mg 2+ first and continuously Zn 2+ . More importantly, the release of Zn 2+ from bilayered PLGA endowed GBR membranes with excellent antibacterial activity (antibacterial rate > 69.3%) as well as good cytocompatibility with MC3T3-E1 (mouse calvaria pre-osteoblastic cells) and HGF-1 (human gingival fibroblast cells). Thus, the asymmetric bi-layered PLGA membranes embedded with Mg and Zn particles provide a simple and effective strategy to not only reinforce the PLGA membrane but also endow membranes with osteogenic and antibacterial activity due to the continuous ion release profile, which serves as a promising candidate for use in GBR therapy.

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Underestimated microbial infection of resorbable membranes on guided regeneration

Cited by 14 publications

References 157 publications

Dynamic hydrogel–metal–organic framework system promotes bone regeneration in periodontitis through controlled drug delivery

Dynamic hydrogel–metal–organic framework system promotes bone regeneration in periodontitis through controlled drug delivery

Recent Advances in Functionalized Electrospun Membranes for Periodontal Regeneration

Incorporation of Magnesium and Zinc Metallic Particles in PLGA Bi-layered Membranes with Sequential Ion Release for Guided Bone Regeneration

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