Under-utilization of taps in intensive care unit as a cause of reservoirs of nonfermenting gram-negative bacilli

de-las-Casas-Cámara, Gonzalo; Martín-Ríos, María Dolores; Adillo-Montero, Maria Isabel; Muñoz-Egea, María-Carmen; Zapardiel-Ferrero, Javier; Peremarch, Concepción Pérez-Jorge

doi:10.1016/j.eimce.2018.02.010

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Previous studies have found that E. meningoseptica could be identified in hospital environments, including in saline solutions, water supplies, disinfectants, equipment surfaces and medical devices with fluids (respirators, intubation tubes, humidifiers). 3 , 4 , 30 , 31 Therefore, risk factors for E. meningoseptica infection are complex and need special attention in clinical settings.…”

Section: Discussionmentioning

confidence: 99%

Emerging Prevalence and Clinical Features of Elizabethkingia meningoseptica Infection in Southwest China: A 9-Year Retrospective Study and Systematic Review

Ma¹,

Gong²,

Luo³

et al. 2023

IDR

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Background Elizabethkingia meningoseptica infections have gradually emerged as life-threatening nosocomial infections worldwide, accompanied by increasing incidence, multidrug resistance and poor outcomes. However, the epidemiology and clinical features of E. meningoseptica infection are still limited in mainland China. Methods Patients with E. meningoseptica infections from 2011 to 2019 in southwestern China were retrospectively analyzed. The clinical features, infection patterns and outcomes were extracted from medical records and analyzed. A comprehensive systematic review was performed in accordance with PRISMA guidelines from conception to August 23, 2021. Results Ninety-two patients were ultimately included, with the prevalence rapidly rising from 0 in 2011 to 0.19 per 1000 inpatients in 2019. A total of 93.48% of E. meningoseptica isolates were multidrug resistant, including 100% resistance to carbapenem. Furthermore, 75% of E. meningoseptica infections were concomitant with other pathogens. The mortality of our cohort was 36.96%, with risk factors for mechanical ventilation (OR=9.51, P=0.004), male sex (OR=0.27, P=0.031) and more concomitant pathogens. After propensity score matching, central venous catheters, exposure to carbapenem and antifungal drugs, and underlying tumors were associated with E. meningoseptica infection. Sixteen articles were also summarized, with reported mortality rates ranging from 11.0% to 66.6%. Blood and respiratory tract were the common sources. Piperacillin/tazobactam, trimethoprim/sulfamethoxazole, fluoroquinolone and minocycline were the most sensitive antibiotics. Inappropriate antibiotic treatment was the most commonly reported risk factor for mortality. Conclusion Nosocomial infection with E. meningoseptica has become an emerging problem with high mortality in southwestern China. Inappropriate antibiotic treatment and central venous catheters are risk factors for infection and death and should receive adequate attention.

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Section: Discussionmentioning

confidence: 99%

Emerging Prevalence and Clinical Features of Elizabethkingia meningoseptica Infection in Southwest China: A 9-Year Retrospective Study and Systematic Review

Ma¹,

Gong²,

Luo³

et al. 2023

IDR

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“…Epidemiological reports related to E. meningoseptica infection show that Taiwan had the highest number of reported cases, with a mortality rate of 63.2% [3]. Reports from South Korea, Spain, the United Kingdom, India, and Taiwan show that E. meningoseptica can survive in hospital sinks, faucets, humidi ers, and other ward environments and on medical equipment and can cause nosocomial outbreaks [20][21][22][23]. These ndings and the broad resistance of E. meningoseptica in our hospital indicate that E. meningoseptica infection is a serious threat to people's health and lives; furthermore, the possibility that serious nosocomial infections may recur in speci c populations, such as ICU patients or those with weakened immunity, cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study and Analysis of Risk Factors for Elizabethkingia Meningoseptica Infection in a Large General Hospital in China

Gong¹,

Luo²,

Yuan³

et al. 2021

Preprint

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Background As a kind of nosocomial infection pathogen which can cause high mortality, its susceptibility and death risk factors are still unclear. Aim To analyze the epidemiological characteristics of and risk factors for Elizabethkingia meningoseptica infection. Methods Relevant literature from 2011 to 2019 with the key words “E. meningoseptica” or “Elizabethkingia meningoseptica” in the title and abstract was retrieved from the PubMed database. The risk factors of infection and death for infected patients treated at Southwest Hospital during the above period were analyzed by logistic regression. Results From 2011 to 2019, 366 patients infected with E. meningoseptica were reported in 132 articles in the PubMed database. The mortality rate was 63.20%. During the same period, 92 infected patients were treated at our hospital. The overall mortality rate was approximately 28.3% (26/92) to 39.1% (36/92). The resistance rate for carbapenems was 100%; for cephalosporins, it was more than 90%; and for minocycline, it was 0. Central venous catheterization (p < 0.001), mechanical ventilation (p = 0.015), bacteria type (p < 0.001), operation type (p = 0.001), fungal infection (p < 0.001), carbapenem use (p = 0.000), and triazole use (p = 0.016) were independent risk factors for E. meningoseptica infection. According to logistic regression, bacteria type (p = 0.037), platelet level (p = 0.014), and mechanical ventilation (p = 0.043) were risk factors for death. Conclusion The incidence of E. meningoseptica infection worldwide shows a trend toward increasing yearly. Invasive operations, multiple bacterial or fungal infections and the use of carbapenems may be predisposing factors, and platelet level, bacteria type, and mechanical ventilation were risk factors for death.

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“…It has also been postulated to be a potential pathogen in critically ill patients. 1,[4][5][6] Several healthcare-facility outbreaks of NFGNB and Enterobacteriaceae related to contaminated drainage system water have been described. 7,8 Immunocompromised host and critically ill adults as well as neonates are the groups most commonly affected.…”

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confidence: 99%

A cluster of Chryseobacterium indologenes cases related to drainage water in intensive care units

Cantero

Parra

Múñez

et al. 2018

Infect. Control Hosp. Epidemiol.

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In this outbreak, 12 patients in intensive care units acquired a Chryseobacterium indologenes infection. Cultures from sinkholes and air samples were positive for C. indologenes. After removing wash basins, no new cases appeared. Sinkholes, potentially contaminated, can act as a reservoir for C. indologenes and other microorganisms. Thus, patients and equipment should be protected from sink splashes to avoid contamination.

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Under-utilization of taps in intensive care unit as a cause of reservoirs of nonfermenting gram-negative bacilli

Cited by 3 publications

References 7 publications

Emerging Prevalence and Clinical Features of Elizabethkingia meningoseptica Infection in Southwest China: A 9-Year Retrospective Study and Systematic Review

Emerging Prevalence and Clinical Features of Elizabethkingia meningoseptica Infection in Southwest China: A 9-Year Retrospective Study and Systematic Review

Epidemiological Study and Analysis of Risk Factors for Elizabethkingia Meningoseptica Infection in a Large General Hospital in China

A cluster of Chryseobacterium indologenes cases related to drainage water in intensive care units

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