Undenatured Collagen Type Ii for the Treatment of Osteoarthritis of the Knee

Abstract

Objective: To test the hypothesis that undenatured type II collagen (UC-II) relieves pain, quality of life, and joint function in women aged from 60 to 80 years with knee osteoarthritis. Methods: 53 patients in the UC-II treatment group (for 90 days) and 52 in the control group (without UC-II) were evaluated at 1, 30, and 90 days regarding health-related quality of life, pain, and function with questionnaires, anthropometric data, alignment, range of motion, and radiographic analysis. Results: Quality of life increased significantly in the Physical domain in the treatment vs control group. Also, there was a difference between the first and the last evaluation on the pain visual analog scale (−3.8 ± 1.8 versus −1.3 ± 2.0) and on the WOMAC score (−9.5 ± 11.9 versus −1.3 ± 11.1). No variation in the temporal evolution of the Mental domain was found. Conclusion: Pain, joint stiffness, and quality of life (Physical domain) improved with the inclusion of UC-II for 90 days to the therapeutic toolbox for knee osteoarthritis in individuals aged 60 to 80 years. Level of evidence II, Comparative Prospective Study.

The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats

“…Many animal [22][23][24][25] and human 18,26,27 studies have demonstrated a beneficial effect of undenatured collagen administration on OA; however, the effects of undenatured collagen in different doses and age groups have not been investigated. The present study is the first to compare the efficacy of different doses of undenatured collagen on MIA-induced OA in young and old rats.…”

“…Previous studies show that OA treatment using undenatured collagen alleviates joint pain and improves quality of life 27 . Although a low dose of undenatured collagen did not effectively attenuate joint cartilage damage in old rats, the present findings show that all doses of undenatured collagen supplementation reduced knee swelling and improved gait patterns, closely related to pressure pain thresholds.…”

Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D₃ and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint

“…(2022 г.) [26] НК-II изучен у пожилых пациентов (60-80 лет) с ОА, осложненным различными проявлениями метаболического синдрома. Ввиду сложности выбора симптом-модифицирующей терапии для коморбидных пациентов с ограничениями к назначению или прямыми противопоказаниями для назначения НПВП (СД, неконтролируемая АГ, хроническая болезнь почек) возможность применения у них исследуемой комбинации имеет важное практическое значение.…”

Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge

“…Up to date, several clinical trials regarding the use of collagen as a food supplement for joint health have been published. Most of the studies have evaluated the therapeutic potential of either native type II collagen [ 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ] or hydrolyzed collagens [ 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ] in patients with OA. However, both types of collagens have been also tested in non-osteoarthritic individuals suffering joint discomfort [ 108 , 109 , 110 , 111 , 112 , 113 ].…”