Uncovering the neuron’s internal skeleton

Dance, Amber

doi:10.1073/pnas.1617651113

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…It is also possible that other unidentified, AISspecific 'pickets' might selectively impede the lateral diffusion of plasma membrane pro teins at this locale, explaining the lack of restriction of diffusion seen in distal axons. The functions of deep actin assemblies such as hot spots and trails are not well understood 174 . Available data suggest that these dynamics help deposit actin at en-passant boutons and sustain presynaptic function 148 .…”

Section: Microfluidicmentioning

confidence: 99%

The nano-architecture of the axonal cytoskeleton

2017

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The corporeal beauty of the neuronal cytoskeleton has captured the imagination of generations of scientists. One of the easiest cellular structures to visualize by light microscopy, its existence has been known for well over 100 years, yet we have only recently begun to fully appreciate its intricacy and diversity. Recent studies combining new probes with super-resolution microscopy and live imaging have revealed surprising details about the axonal cytoskeleton and, in particular, have discovered previously unknown actin-based structures. Along with traditional electron microscopy, these newer techniques offer a nanoscale view of the axonal cytoskeleton, which is important for our understanding of neuronal form and function, and lay the foundation for future studies. In this Review, we summarize existing concepts in the field and highlight contemporary discoveries that have fundamentally altered our perception of the axonal cytoskeleton.

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Section: Microfluidicmentioning

confidence: 99%