Uncovering the mechanism of the Shenzhi Jiannao formula against vascular dementia using a combined network pharmacology approach and molecular biology

Tian, Danfeng; Gao, Qiang; Lin, Jingfeng; Chang, Ze; Shi, Yuanyuan; Su, Rui; Han, Zhijie; Ma, Dayong

doi:10.1016/j.phymed.2021.153637

Cited by 23 publications

(13 citation statements)

References 60 publications

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“…Phytomolecules like Luteolin and luteolin analogs ( Delgado et al, 2021 ), Vitexin ( Malar et al, 2020 ; Zhang et al, 2021 ), Quercetin ( Yao et al, 2010 ), Torosaflavone E ( Khamphukdee et al, 2021 ), Demethyl torosaflavone D ( Khamphukdee et al, 2021 ), β-Sitosterol ( Kim et al, 2008 ), Stigmasterol ( Park S. J. et al, 2012 ; Pratiwi et al, 2021 ), Ursolic acid ( Habtemariam, 2019 ), Oleanolic acid and oleanolic acid analogs ( Lin et al, 2021 ), Caffeic acid ( Khan et al, 2013 ; Deshmukh et al, 2016 ), Quinic acid ( Liu et al, 2020 ), p-Coumaric acid ( Kim H.-B. et al, 2017 ), β-Carboline ( Zhao et al, 2013 ; Li et al, 2018 ), Malic acid ( Tian et al, 2021 ), Blumenol A ( Emir et al, 2019 ), Phytol ( Sathya et al, 2020 ), and Pheophytin A ( Park et al, 2014 ) which were earlier reported from Alternanthera philoxeroides (Mart.) Griseb., may be responsible for this antidementia property.…”

Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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Ethnopharmacological relevance: The genus Alternanthera (Amaranthaceae) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders.Aim of the review: To search research gaps through critical assessment of pharmacological activities not performed to validate traditional claims of various species of Alternanthera. This review will aid natural product researchers in identifying Alternanthera species with therapeutic potential for future investigation.Materials and methods: Scattered raw data on ethnopharmacological, morphological, phytochemical, pharmacological, toxicological, and clinical studies of various species of the genus Alternanthera have been compiled utilizing search engines like SciFinder, Google Scholar, PubMed, Science Direct, and Open J-Gate for 100 years up to April 2021.Results: Few species of Alternanthera genus have been exhaustively investigated phytochemically, and about 129 chemical constituents related to different classes such as flavonoids, steroids, saponins, alkaloids, triterpenoids, glycosides, and phenolic compounds have been isolated from 9 species. Anticancer, antioxidant, antibacterial, CNS depressive, antidiabetic, analgesic, anti-inflammatory, and immunomodulator effects have been explored in the twelve species of the genus. A toxicity study has been conducted on 3 species and a clinical study on 2 species.Conclusions: The available literature on pharmacological studies of Alternanthera species reveals that few species have been selected based on ethnobotanical surveys for scientific validation of their traditional claims. But most of these studies have been conducted on uncharacterized and non-standardized crude extracts. A roadmap of research needs to be developed for the isolation of new bioactive compounds from Alternanthera species, which can emerge out as clinically potential medicines.

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Section: Introductionmentioning

confidence: 99%

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

et al. 2022

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“…Wolf, and Cyclocarya paliurus [Batal.] Iljinskaja leaves) that could enter the serum were considered to be potential active compounds for network pharmacology analysis [17] , [18] , [19] , [20] , [21] , [22] . The compounds present in other biological samples, such as urine and tissues, could be also used for network pharmacology analysis [23] , [24] .…”

Section: Network Pharmacology For Chm Researchmentioning

confidence: 99%

Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review

Wang

Yang

Wang

et al. 2022

Journal of Integrative Medicine

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“…Facing the dilemma that there are still no drugs for VaD, TCM is a huge resource for the explanation on VaD. TCM plays a more and more important role in the prevention and treatment of VaD and gradually shows a great application prospect [ 2 , 11 , 12 ]. However, the use of TCM in the treatment of VaD still lacks the corresponding theoretical basis.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Deciphering the Potential Biomarkers of Hengqing I Prescription against Vascular Dementia

Meng

Li²,

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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With the aging of population, vascular dementia (VaD) seriously threatens people’s health and quality of life. It is of great significance to explore biomarkers of VaD from the perspective of metabolomics and traditional Chinese medicine (TCM). Therefore, VaD was divided into kidney deficiency and blood stasis syndrome (KDBS) and non-KDBS according to TCM. Then, some patients received the treatment of Hengqing I (HQI) prescription. The urine of six groups (VaD group, normal group, KDBS group, non-KDBS group, HQI group, and control group) was detected on LC-MS/MS. Multivariate statistical analysis showed that the metabolic profiles of the three comparisons were significantly different. The top analysis-ready molecules of downregulated histamine and upregulated biotin, methionine, pantothenic acid, SAH, histidine, and kaempferol may be the most related metabolites. These putative biomarkers play an important role in the regulation of key metabolic processes linked to VaD. Additionally, pathway analysis showed aminoacyl-tRNA biosynthesis, and amino acids metabolic pathways were highly correlated with the occurrence of VaD. In this present paper, vitamins, amino acids, and their derivatives were selected as the basis for VaD diagnosis and treatment monitoring, and the significance of TCM classification and Hengqing I prescription in the treatment of VaD was discussed.

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Uncovering the mechanism of the Shenzhi Jiannao formula against vascular dementia using a combined network pharmacology approach and molecular biology

Cited by 23 publications

References 60 publications

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives

Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review

Metabolomics Deciphering the Potential Biomarkers of Hengqing I Prescription against Vascular Dementia

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