Uncovering the influence of diet and gut microbiota in human serum metabolome

Obeso, David; Zubeldia‐Varela, Elisa; Villaseñor, Alma

doi:10.1111/all.14770

Cited by 2 publications

(1 citation statement)

References 11 publications

(28 reference statements)

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“…Metabolomics focuses on studying compounds defined as metabolites that encompass the metabolism of a living organism/tissue/cell [8]. This is a valuable tool for biomarker discovery, predicting response to therapy and potential pathogenic pathways for various complex diseases, such as asthma.…”

Section: Metabolomicsmentioning

confidence: 99%

Metabolomics in the Identification of Biomarkers of Asthma

et al. 2021

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Section: Metabolomicsmentioning

confidence: 99%

Metabolomics in the Identification of Biomarkers of Asthma

et al. 2021

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The impact of high‐IgE levels on metabolome and microbiome in experimental allergic enteritis

Zubeldia‐Varela,

Blanco‐Pérez,

Barker‐Tejeda

et al. 2024

Allergy

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BackgroundThe pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma and anaphylaxis Importantly, high‐IgE levels are a poor prognostic factor in gastrointestinal allergies.MethodsThis study investigated how high‐IgE levels influence the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock‐in (IgEki) mice expressing high levels of IgE. In addition, correlation of the altered metabolome with gut microbiome was analysed.ResultsOvalbumin‐sensitized and egg‐white diet‐fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulation. Untargeted metabolomics detected the increased levels of N‐tau‐methylhistamine and 2,3‐butanediol, and reduced levels of butyric acid in faeces and/or sera of OVA/EW IgEki mice, which was accompanied with reduced Clostridium and increased Lactobacillus at the genus level. Non‐sensitized and egg‐white diet‐fed (NC/EW) WT mice did not exhibit any signs of AE, whereas NC/EW IgEki mice developed marginal degrees of AE. Compared to NC/EW WT mice, enhanced levels of lysophospholipids, sphinganine and sphingosine were detected in serum and faecal samples of NC/EW IgEki mice. In addition, several associations of altered metabolome with gut microbiome—for example Akkermansia with lysophosphatidylserine—were detected.ConclusionsOur results suggest that high‐IgE levels alter intestinal and systemic levels of endogenous and microbiota‐associated metabolites in experimental AE. This study contributes to deepening the knowledge of molecular mechanisms for the development of AE and provides clues to advance diagnostic and therapeutic strategies of allergic diseases.

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Uncovering the influence of diet and gut microbiota in human serum metabolome

Cited by 2 publications

References 11 publications

Metabolomics in the Identification of Biomarkers of Asthma

Metabolomics in the Identification of Biomarkers of Asthma

The impact of high‐IgE levels on metabolome and microbiome in experimental allergic enteritis

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