Uncovering the Influence Mechanism of Solvent on Crystal Morphology via a Combined Experimental and Theoretical Method: The Case of Aceclofenac
Longping Jiang,
Mengmeng Wang,
Wenqian Chen
et al.
Abstract:Aceclofenac (ACF) is a kind of antipyretic, analgesic, and antiarthritic drug, which is clinically suitable for the treatment of rheumatoid arthritis. However, the morphology of ACF produced in the crystallization process is easily regulated by different solvents, which has a significant effect on the powder properties of the ACF crystals. Therefore, the study of crystal habits is needed for producing ACF with a better performance. In this study, the effects of different solvents on the growth of the ACF cryst… Show more
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