Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants
Jieye Lin,
Guanhong Bu,
Johan Unge
et al.
Abstract:Most treatments to alleviate major depression work by either inhibiting human monoamine transporters, vital for the reuptake of monoamine neurotransmitters, or by inhibiting monoamine oxidases, which are vital for their degradation. The analysis of the experimental 3D structures of those antidepressants in their drug formulation state is key to precision drug design and development. In this study, microcrystal electron diffraction (MicroED) is applied to reveal the atomic 3D structures for the first time of fi… Show more
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