2022
DOI: 10.1016/j.aca.2022.339617
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Uncovering the behaviour of ions in the gas-phase to predict the ion mobility separation of isomeric steroid compounds

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Cited by 11 publications
(18 citation statements)
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“…Bile acids (BA) are steroids synthesised in the liver from cholesterol. The primary BA cholic acid, and its derivatives, exhibited measurable ion mobility differences upon investigation by DI-TWIMS ( Hadavi et al, 2022 ). A representative isomeric pair from this study is glycodeoxycholic acid (GDCA) and glycochenodeoxycholic acid (GCDCA), whose structural differences are related to the position of the hydroxyl group on C7 and C12, respectively.…”
Section: Ims-ms Approaches Towards the Separation Of Geometrical Lipi...mentioning
confidence: 99%
See 3 more Smart Citations
“…Bile acids (BA) are steroids synthesised in the liver from cholesterol. The primary BA cholic acid, and its derivatives, exhibited measurable ion mobility differences upon investigation by DI-TWIMS ( Hadavi et al, 2022 ). A representative isomeric pair from this study is glycodeoxycholic acid (GDCA) and glycochenodeoxycholic acid (GCDCA), whose structural differences are related to the position of the hydroxyl group on C7 and C12, respectively.…”
Section: Ims-ms Approaches Towards the Separation Of Geometrical Lipi...mentioning
confidence: 99%
“…Conversely, multiple sodium monomers presented a bulky conformation with a poorer separation between isomers. Thus, the presence of multiple adducts does not necessarily increase their ΔCCS value ( Hadavi et al, 2022 ).…”
Section: Ims-ms Approaches Towards the Separation Of Geometrical Lipi...mentioning
confidence: 99%
See 2 more Smart Citations
“…19 Bile acids comprise a structurally challenging subclass, due to the presence of numerous hydroxyl group positional and stereochemical isomers, but further incorporation of complementary computational modeling could assist in identification. 20 IM-MS has even seen utility in identifying steroids in food safety applications. 21−23 Other steroid subclasses that have been profiled using IM-MS have included vitamin D metabolites, 24 glucorocorticoids, 11 and serum estrogens.…”
Section: ■ Introductionmentioning
confidence: 99%