Uncoupling Protein 2 in Cardiovascular Health and Disease

Tian, Xiaoyu; Ma, Shuangtao; Tse, Gary; Wong, Wing Tak; Huang, Yu

doi:10.3389/fphys.2018.01060

Cited by 69 publications

(57 citation statements)

References 130 publications

(140 reference statements)

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“…UCP2 has also been reported to regulate oxidative stress in other diseases. For instance, UCP2 deficiency promotes oxidative stress in cardiovascular diseases [33]. Likewise, in our study, the knock-down of UCP2 suppressed the effects of Klotho on H 2 O 2 -induced oxidative stress and apoptosis in PDLSCs.…”

Section: Discussionsupporting

confidence: 72%

Klotho inhibits H 2 O 2 -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression

Zhu

Xie

Liu

et al. 2020

Preprint

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Background Periodontitis, known as a human chronic inflammatory disease, has affected the life of millions of individuals. Known risk factors such as metabolic disease and oxidative stress have been reported to be closely associated with the initiation or development of periodontitis. However, the etiology of periodontitis remains unclear. Klotho, a single-pass transmembrane protein, has been widely reported to modulate cellular processes in various diseases. However, the role of Klotho in periodontitis is unknown.Results In this study, we designed and conducted a series of experiments to evaluate the role of Klotho in chronic periodontitis. Our experimental results showed that Klotho was downregulated in the gingival tissues, gingival crevicular fluid (GCF), and periodontal ligament stem cells (PDLSCs) of chronic periodontitis patients. Besides, Klotho upregulated the production of uncoupling protein 2 (UCP2) in H2O2-treated PDLSCs. In function, Klotho inhibited H2O2-induced oxidative stress and cellular apoptosis in PDLSCs. Moreover, the rescue assay suggested that UCP2 knock-down suppressed the effects of Klotho on H2O2-induced oxidative stress and apoptosis in PDLSCs.Conclusions In conclusion, we found that Klotho inhibits H2O2-induced oxidative stress and apoptosis in PDLSCs by regulating UCP2 expression. This novel discovery may provide a potential target for chronic periodontitis treatment.

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Section: Discussionsupporting

confidence: 72%

Klotho inhibits H 2 O 2 -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression

Zhu

Xie

Liu

et al. 2020

Preprint

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“…Uncoupling proteins (UCPs) are present in the inner mitochondrial membrane and allow the entry of protons into the mitochondrial matrix, resulting in both the generation of heat and attenuation of oxidant production (23,24). To determine whether the increased proton leak observed in older adults was due to upregulation of UCPs, we measured the protein abundance of UCP2.…”

Section: L I N I C a L M E D I C I N Ementioning

confidence: 99%

Platelet bioenergetics correlate with muscle energetics and are altered in older adults

Braganza¹,

Corey²,

Santanasto³

et al. 2019

JCI Insight

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P-MRS were also performed in older adults. RESULTS. Maximal and ATP-linked respiratory rate measured in platelets from older adults correlated significantly with muscle maximal respiration (r = 0.595; P = 0.003) and maximal ATP production (r = 0.643; P = 0.004; by 31 P-MRS) in the same individuals. Comparison of platelet bioenergetics in older and younger adults showed lower basal and ATP-linked respiration in older adults. Platelets from older adults also showed enhanced proton leak, which was due to increased protein levels of uncoupling protein 2, and correlated with gate speed (r = 0.58; P = 0.0019). While no significant difference in glycolysis was observed in older compared to younger adults, platelet glycolytic rate correlated with fatigability (r = 0.44; P = 0.016). CONCLUSION. These data advance the mechanistic understanding of age-related changes in mitochondrial function. Further, they suggest that measuring platelet bioenergetics provides a potential supplement or surrogate for muscle biopsy measurement and may be a valuable tool to study mitochondria in age-related decline of physical function.

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“…The association between UCPs and hypertension was discovered in lab studies [29,30], and was verified in Asian population [31,32]. Molecular epidemiology studies found UCP2 polymorphism alters the risk of developing CAD in some populations [33,34], while the relation between UCPs and obesity was widely recognized in several populations [35][36][37].…”

Section: Discussionmentioning

confidence: 89%

Analysis of association between common variants of uncoupling proteins genes and diabetic retinopathy in a Chinese population

Jin

et al. 2020

BMC Med Genet

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Background: The aim of this study was to explore the association between diabetic retinopathy (DR) and the variants of uncoupling proteins (UCPs) genes in a Chinese population of type 2 diabetes, in total and in patients of different glycemic status separately. Methods: This case-control study included a total of 3107 participants from two datasets, among which 662 were DR patients (21.31%). Eighteen tag single nucleotide polymorphisms (SNPs) of UCP1, UCP2, and UCP3 were selected as genetic markers. TaqMan probes, Sequenom MassARRAY MALDI-TOF mass spectrometry platform and Affymetrix Genome-Wide Human SNP Array were used for genotyping. Online SHEsis software was used for association analysis. Bonferroni correction was used for multiple comparisons correction. Results: Three SNPs of UCP1: rs7688743 (A allele, OR = 1.192, p = 0.013), rs3811787 (T allele, OR = 0.863, p = 0.023), and rs10011540 (G allele, OR = 1.368, p = 0.004) showed association with DR after the adjustment of glucose, but only rs10011540 was marginally significantly associated with DR when Bonferroni correction was strictly applied (p adj = 0.048). In patients with uncontrolled glucose, rs7688743 (A allele, p = 0.012, OR = 1.309), rs10011540 (G allele, p = 0.033, OR = 1.432), and rs3811787 (T allele, p = 0.022, OR = 0.811) were associated with DR, while in participants with well controlled glucose, the rs2734827 of UCP3 was associated with DR (A allele, p = 0.017, OR = 0.532). Rs3811787 of UCP1 showed a protective effect to sight threatening DR (T allele, p = 0.007, OR = 0.490), and the association existed after the adjustment for environmental factors and the correction. In patients with uncontrolled glucose, the rs3811787 of UCP1 (T allele, p = 0.017, OR = 0.467) and the rs591758 of UCP3 (C allele, p = 0.026, OR = 0.103) were associated with STDR. While in those with well controlled glucose, only the rs7688743 of UCP1 showed a protective effect (A allele, p = 0.024, OR = 0.049). None of the associations remain significant when Bonferroni correction was strictly applied (all p < 0.05).

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Uncoupling Protein 2 in Cardiovascular Health and Disease

Cited by 69 publications

References 130 publications

Klotho inhibits H 2 O 2 -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression

Klotho inhibits H 2 O 2 -induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression

Platelet bioenergetics correlate with muscle energetics and are altered in older adults

Analysis of association between common variants of uncoupling proteins genes and diabetic retinopathy in a Chinese population

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