Unconventional Roles of Opsins

Leung, Nicole Y.; Montell, Craig

doi:10.1146/annurev-cellbio-100616-060432

Cited by 111 publications

(112 citation statements)

References 165 publications

Supporting

Mentioning

110

Contrasting

Order By: Relevance

“…Work on Drosophila has shown that opsins, the protein moieties of visual photopigments, not only detect light (Leung and Montell, 2017). Opsins were implicated in larval temperature preference behaviors (Shen et al, 2011;Sokabe et al, 2016) and in hearing in the adult flies (Senthilan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, opsins were surmised to have light-independent ancestral functions (Shen et al, 2011;Senthilan et al, 2012), yet what these functions are remains a mystery. In thermosensation, opsins, though usually thermo-stable, were proposed to act as thermosensors (Shen et al, 2011;Leung and Montell, 2017), and how opsins contribute sound transduction is unclear (Albert and Gö pfert, 2015;Leung and Montell, 2017). Locomotion is a hallmark of animal life, and the need for movement control presumably was a driving factor in early nervous system evolution (Jé kely et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proprioceptive Opsin Functions in Drosophila Larval Locomotion

Zanini

Giraldo

Warren

et al. 2018

Neuron

View full text Add to dashboard Cite

Animals rely on mechanosensory feedback from proprioceptors to control locomotory body movements. Unexpectedly, we found that this movement control requires visual opsins. Disrupting the Drosophila opsins NINAE or Rh6 impaired larval locomotion and body contractions, independently of light and vision. Opsins were detected in chordotonal proprioceptors along the larval body, localizing to their ciliated dendrites. Loss of opsins impaired mechanically evoked proprioceptor spiking and cilium ultrastructure. Without NINAE or Rh6, NOMPC mechanotransduction channels leaked from proprioceptor cilia and ciliary Inactive (Iav) channels partly disappeared. Locomotion is shown to require opsins in proprioceptors, and the receptors are found to express the opsin gene Rh7, in addition to ninaE and Rh6. Besides implicating opsins in movement control, this documents roles of non-ciliary, rhabdomeric opsins in cilium organization, providing a model for a key transition in opsin evolution and suggesting that structural roles of rhabdomeric opsins preceded their use for light detection.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Proprioceptive Opsin Functions in Drosophila Larval Locomotion

Zanini

Giraldo

Warren

et al. 2018

Neuron

View full text Add to dashboard Cite

show abstract

“…Increased SWS1 opsin expression has been found in the damselfish, P. nagasakiensis during winter months and may be a visual tuning response for taking advantage of the higher UV . Seasonal changes in opsin gene expression levels have been reported to alter colour perception in widespread taxa (see review by Shimmura et al 2018 Leung & Montell, 2017) and most recently in taste (Leung et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Seeing Nemo: molecular evolution of ultraviolet visual opsins and spectral tuning of photoreceptors in anemonefishes (Amphiprioninae)

Mitchell

Cheney

Chung

et al. 2020

Preprint

View full text Add to dashboard Cite

Many animals can see short-wavelength or ultraviolet (UV) light (shorter than 400 nm) undetectable to human vision. UV vision may have functional importance in many taxa including for foraging and communication in birds, reptiles, insects and teleost fishes.Shallow coral reefs transmit a broad spectrum of light and are rich in UV; driving the evolution of diverse spectral sensitivities in teleost reef fishes, including UV-sensitivity.However, the identities and sites of the specific visual genes that underly vision in reef fishes remain elusive and are useful in determining how molecular evolution has tuned vision to meet the ecological demands of life on the reef. We investigated the visual systems of eleven anemonefish (Amphiprioninae) species, specifically probing for the molecular pathways that facilitate UV-sensitivity. Searching the genomes of anemonefishes, we identified a total of seven functional visual genes from all five vertebrate opsin gene subfamilies. We found rare instances of UV-sensitive SWS1 opsin gene duplications, that produced two functional paralogs (SWS1α and SWS1β) and a pseudogene. We also found separate RH2A opsin gene duplicates which has not been previously reported in the family Pomacentridae. Finally, we report on the visual opsin gene expression levels measured in the adult retina of the false clown anemonefish (Amphiprion ocellaris), and their photoreceptor spectral sensitivities measured using microspectrophotometry.

show abstract

“…Therefore we expect that, in the near future, increasing both the number and the quality such single cell transcriptomes for these and other species will be useful to address several questions about the evolution of specific cell fates. For example, some opsins may have other functions apart from light-sensing [73], and it would be relevant to know if glass regulates the expression of any such opsin outside the Platynereis eye (for example), at any stage.…”

Section: Discussionmentioning

confidence: 99%

Glass confers rhabdomeric photoreceptor identity inDrosophila, but not across all metazoans

Bernardo-Garcia

Syed

Jékely

et al. 2018

Preprint

View full text Add to dashboard Cite

Across metazoans, visual systems employ different types of photoreceptor neurons to detect light. These include rhabdomeric PRs, which exist in distantly related phyla and possess an evolutionarily conserved phototransduction cascade. While the development of rhabdomeric PRs has been thoroughly studied in the fruit fly Drosophila melanogaster, we still know very little about how they form in other species. To investigate this question, we tested whether the transcription factor Glass, which is crucial for instructing rhabdomeric PR formation in Drosophila, may play a similar role in other metazoans. Glass homologues exist throughout the animal kingdom, indicating that this protein evolved prior to the metazoan radiation. Interestingly, our work indicates that glass is not expressed in rhabdomeric photoreceptors in the planarian Schmidtea mediterranea nor in the annelid Platynereis dumerilii. Combined with a comparative analysis of the Glass DNA-binding domain, our data suggest that the fate of rhabdomeric PRs is controlled by Glass-dependent and Glass-independent mechanisms in different animal clades.

show abstract

Unconventional Roles of Opsins

Cited by 111 publications

References 165 publications

Proprioceptive Opsin Functions in Drosophila Larval Locomotion

Proprioceptive Opsin Functions in Drosophila Larval Locomotion

Seeing Nemo: molecular evolution of ultraviolet visual opsins and spectral tuning of photoreceptors in anemonefishes (Amphiprioninae)

Glass confers rhabdomeric photoreceptor identity inDrosophila, but not across all metazoans

Contact Info

Product

Resources

About