Unconventional Methods for Fabricating and Patterning Nanostructures

Xia, Younan; Rogers, John A.; Paul, Kateri E.; Whitesides, George M.

doi:10.1021/cr980002q

Cited by 1,568 publications

(1,240 citation statements)

References 279 publications

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“…Fortunately, Au surfaces can be functionalized with a variety of molecules and ligands using the well-established thiolate-Au monolayer chemistry. [25] Sulfur has a particularly strong affinity for Au (85 to 145 kJ/mol), with organosulfur molecules such as octadecanethiol spontaneously assembling into stable and highly organized layers on Au surfaces. This so-called self-assembled monolayer (or SAM) binds to a Au surface through the sulfur atoms and form an interface defined primarily by the head group (i.e., in the case of octadecanethiol, a methyl group).…”

Section: Bioconjugation Of Au Nanocagesmentioning

confidence: 99%

Gold Nanocages for Biomedical Applications

et al. 2007

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Nanostructured materials provide a promising platform for early cancer detection and treatment.Here we highlight recent advances in the synthesis and use of Au nanocages for such biomedical applications. Gold nanocages represent a novel class of nanostructures, which can be prepared via a remarkably simple route based on the galvanic replacement reaction between Ag nanocubes and HAuCl 4 . The Au nanocages have a tunable surface plasmon resonance peak that extends into the near-infrared, where the optical attenuation caused by blood and soft tissue is essentially negligible. They are also biocompatible and present a well-established surface for easy functionalization. We have tailored the scattering and absorption cross-sections of Au nanocages for use in optical coherence tomography and photothermal treatment, respectively. Our preliminary studies show greatly improved spectroscopic image contrast for tissue phantoms containing Au nanocages. Our most recent results also demonstrate the photothermal destruction of breast cancer cells in vitro by using immuno-targeted Au nanocages as an effective photo-thermal transducer. These experiments suggest that Au nanocages may be a new class of nanometer-sized agents for cancer diagnosis and therapy.

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Section: Bioconjugation Of Au Nanocagesmentioning

confidence: 99%

Gold Nanocages for Biomedical Applications

et al. 2007

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“…In surface-sensitive biosensing, increasing the specific area of the sensing surface improves the sensitivity, because more target analyte can be captured. One possible way to enlarge the specific area is via surface nanostructuring [29][30][31][32]. However, in the optical techniques an important aspect is that the modification of the sensor must not quench the propagation of light, hence scattering and absorption have to be minimized.…”

Section: Introductionmentioning

confidence: 99%

Enhanced protein adsorption and cellular adhesion using transparent titanate nanotube thin films made by a simple and inexpensive room temperature process: Application to optical biochips

Nádor

Orgován

Fried

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Please cite this article in press as: J. Nador, et al., Enhanced protein adsorption and cellular adhesion using transparent titanate nanotube thin films made by a simple and inexpensive room temperature process: Application to optical biochips, Colloids Surf. a b s t r a c tA new type of titanate nanotube (TNT) coating is investigated for exploitation in biosensor applications. The TNT layers were prepared from stable but additive-free sols without applying any binding compounds. The simple, fast spin-coating process was carried out at room temperature, and resulted in well-formed films around 10 nm thick. The films are highly transparent as expected from their nanostructure and may, therefore, be useful as coatings for surface-sensitive optical biosensors to enhance the specific surface area. In addition, these novel coatings could be applied to medical implant surfaces to control cellular adhesion. Their morphology and structure was characterized by spectroscopic ellipsometry (SE) and atomic force microscopy (AFM), and their chemical state by X-ray photoelectron spectroscopy (XPS). For quantitative surface adhesion studies, the films were prepared on optical waveguides. The coated waveguides were shown to still guide light; thus, their sensing capability remains. Protein adsorption and cell adhesion studies on the titanate nanotube films and on smooth control surfaces revealed that the nanostructured titanate enhanced the adsorption of albumin; furthermore, the coatings considerably enhanced the adhesion of living mammalian cells (human embryonic kidney and preosteoblast).

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“…A reliable, fast, and low-cost process which has the potential to produce robust, homogeneous patterns on areas 0.1m 2 and larger is critical to success in these industries. [1][2][3][4][5][6][7][8][9][10][11][12] Many existing methods currently employed in the production of micropatterns are unsuitable for incorporation into a large area process. Research in areas such as thermal and UV light curing imprint lithography have yielded robust, defect free structures with a resolution as low as 10nm; however, these methods are limited to areas of tens of cm 2 or less.…”

Section: Introductionmentioning

confidence: 99%

A novel process for continuous thermal embossing of large‐area nanopatterns onto polymer films

2009

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Hot embossing and nanoimprinting processes are being widely practiced in industry. Fast and reliable production of micro/nanofeatured patterns on large‐area polymer films is of a great importance. In this study, a novel roll‐to‐roll thermal imprinting process was developed, capable of providing a mold‐heating rate of 125°C/s with sufficient temperature control to produce large‐area patterns continuously at a rapid production rate. With this new process, selected micro/nano patterns were produced on a polyethylene terephthalate film at a production rate exceeding 1 m/min. The roller mold temperature played a profound role in affecting the replication quality. To achieve good feature transfer properties, an elevated roller mold temperature approaching the melting temperature of the polymer was found to be critical. Microcavity filling time calculation further revealed that the elevated roller mold temperature is also necessary for achieving a rapid film feed rate as desired in the continuous roll‐to‐roll process. © 2010 Wiley Periodicals, Inc. Adv Polym Techn 28:246–256, 2009; Published online in Wiley InterScience (http://www.interscience.wiley.com). DOI 10.1002/adv.20167

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Unconventional Methods for Fabricating and Patterning Nanostructures

Cited by 1,568 publications

References 279 publications

Gold Nanocages for Biomedical Applications

Gold Nanocages for Biomedical Applications

Enhanced protein adsorption and cellular adhesion using transparent titanate nanotube thin films made by a simple and inexpensive room temperature process: Application to optical biochips

A novel process for continuous thermal embossing of large‐area nanopatterns onto polymer films

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