Uncontrollable diabetes mellitus: a rare paraneoplastic manifestation of renal cell carcinoma

Hypoglycaemia as a Paraneoplastic Syndrome Associated with Renal Adenocarcinoma in a Dog

“…Metastases to the regional lymph nodes and lungs are common (Moulton, 1990). In humans, several reports describe paraneoplastic syndromes related to kidney neoplasm: fever, myasthenia gravis, diabetes mellitus and diaphragmatic paralysis have been reported (Callewart et al, 1999;Torgerson et al, 1999;Rijnders and Decramer, 2000). Fewer contributions come from veterinary medicine: polycytaemia due to increased production of erythrpoietin and neutrophilic leukocytosis are the most common paraneoplastic syndromes associated with renal tumours (Morrison, 2002).…”

Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature

“…It is important to emphasize that obesity is a risk factor independent of blood pressure, which suggests a different mechanism of action. Obese subjects are more likely to develop clear cell subtype RCC than subjects with a normal BMI (OR, 1.48; 95% CI, 1.19-1.84) (21,22). However, there has also been a study on the Japanese population which demonstrated that BMI did not play a statistically significant role (p=0.991) in the recurrence of RCC (18).…”

New onset hyperglycemia attributed to renal cell carcinoma

“…For instance, in the case of Harada et al, anti-GAD was tested for but was negative (9). For Calleawart and colleagues, glucagon, growth hormone, insulin like growth factor, cortisol and adrenocorticotropic hormone levels were all reported as normal (4). It may be that multiple mechanisms account for these few cases of significant hyperglycemia.…”

“…A review of the literature revealed 7 previously reported cases of RCC with hyperglycemia in the English literature that were available for review (4)(5)(6)(7)(8)(9)(10). Years of publication ranged from 1981 to 2016.…”