Unconjugated estriol in maternal plasma relationship with early fetal development measured by ultrasonic morphometry

Hertogh, R. De; Luyx, A

doi:10.1016/0022-4731(77)90236-9

Cited by 1 publication

(2 citation statements)

References 23 publications

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“…Unconjugated plasma estradiol [3] and estriol [2,3] were measured by radioimmu noassay as described previously.…”

Section: Methodsmentioning

confidence: 99%

“…As a consequence the life span of the corpus luteum is sustained and luteal hormones (estradiol and progester one) are maintained and secondarily increased in the circulation [23]. The developing placenta then takes over the predominant role in steroid hor mone secretion by the 7th to 8th week of pregnancy, producing a further rise in the plasma levels of estradiol and progesterone [3,14], At the same time, HPL starts to increase [3], By the 10th week, the secretion of precursors by the fetal adrenal increases rapidly and produces a steep rise of estriol in maternal plasma [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Hormonal Levels and Ultrasound in Patients with Threatened Abortion

Dessaive

Hertogh²,

Thomas

1982

Gynecol Obstet Invest

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96 women with threatened abortion were monitored by repeated ultrasonic examinations. Simultaneously plasma HCG, progesterone, estradiol and estriol levels were measured. 12 patients with blighted ovum had hormonal levels in the low normal range before the 8th week and abnormal values after the 10th week. 31 patients had abnormal ultrasonic morphology and absence of fetal heart movements. In half of these patients, estradiol was low even before vaginal bleeding. When vaginal bleeding occurred, all subjects who aborted later, except 1, had at least one abnormal hormonal value. In 4 cases, fetal life signs were detected only after the 10th week; hormonal levels remained normal, confirming the presence of a viable fetus. 31 patients had normal ultrasounds despite vaginal bleeding and arrived to term. Hormonal profiles were also normal. 18 patients had normal ultrasounds and aborted in the second trimester of pregnancy. Some of them had low normal hormonal levels. Others had a secondary decrease in hormonal levels (most often estrogen levels) which, in some cases, preceded the abnormality of the ultrasounds. It is concluded that ultrasounds and hormonal measurements are complementary. Ultrasounds alone gave a correct prognosis in 78% of the cases after a single examination. Caution is advised when fetal life signs are absent and termination of pregnancy is contemplated. Hormonal measurements may then confirm or refute the unfavorable prognosis. Also, hormonal measurements may provide some insight as to the subsequent evolution of a threatened pregnancy, even in the presence of normal ultrasounds. The therapeutic prospect of this knowledge is, however, still to be defined.

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“…Unconjugated plasma estradiol [3] and estriol [2,3] were measured by radioimmu noassay as described previously.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation between Hormonal Levels and Ultrasound in Patients with Threatened Abortion

Dessaive

Hertogh²,

Thomas

1982

Gynecol Obstet Invest

Self Cite

View full text Add to dashboard Cite

show abstract

Unconjugated estriol in maternal plasma relationship with early fetal development measured by ultrasonic morphometry

Cited by 1 publication

References 23 publications

Correlation between Hormonal Levels and Ultrasound in Patients with Threatened Abortion

Correlation between Hormonal Levels and Ultrasound in Patients with Threatened Abortion

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