Uncomplicated successful percutaneous transluminal coronary angiopiasty does not affect cardiac troponin T plasma concentrations

Genser, Norbert; Mair, Johannes; Friedrich, Guy; Talasz, Heribert; Moes, N.; Mühlberger, V.; Puschendorf, Bernd

doi:10.1016/s0002-9149(97)89225-9

Cited by 21 publications

(8 citation statements)

References 5 publications

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“…Our results show that overall 26.4% of the patients had abnormal cardiac troponins after elective uncomplicated successful PTCA with or without stent implantation. This result is consistent with previous studies showing a very high diagnostic sensitivity of cTnT versus CKMB in the detection of minor myocardial injury after PTCA [27,28,31]. Cardiac troponins measurement for the monitoring of myocardial injury after coronary stenting was rarely systematically reported [26].…”

Section: Discussionsupporting

confidence: 91%

Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting: Detection by cardiac troponins

Saadeddin

Habbab

Sobki

et al. 2001

Cathet Cardio Intervent

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Cardiac troponins are sensitive and specific markers for the detection of minor myocardial injury. However, they have been rarely used to monitor myocardial injury after coronary stenting. The purpose of the study was to measure cardiac troponin I (cTnI) and cardiac troponin T (cTnT) levels after elective uncomplicated successful percutaneous transluminal coronary angioplasty (PTCA) with or without coronary stenting and to compare their results with serum creatinine kinase MB isoenzyme (CKMB). CTnI and cTnT levels were compared with those of CK or CKMB in 98 consecutive patients with stable angina undergoing elective uncomplicated successful PTCA with stenting (n = 71) or without stenting (n = 27). Markers were measured before and 6, 12, 24, and 48 hr after the procedure. Peak postprocedural levels for each marker were compared and related to angiographic and procedural characteristics as well as to the occurrence of side-branch occlusion. None of the patients had abnormal markers before the procedure. Abnormal postprocedural values of one or more markers were observed in 28 patients (29%), 23 after stenting and 5 after PTCA alone. The frequencies of abnormal cTnI and cTnT levels were significantly higher than that of CKMB after coronary intervention (26% and 18% vs. 7%; P = 0.00016 and 0.015, respectively), with cTnI being the most significant. When compared with troponin-negative patients, abnormal cardiac troponin values were significantly related to total time of inflation (223 +/- 128 vs. 170 +/- 105 sec; P = 0.008) and inflation maximal pressure (12.9 +/- 2.3 vs. 12.0 +/- 2.7 atm; P = 0.04). Small side-branch occlusion was noticed in 36% of the troponin-positive patients and in 6% of the troponin-negative group (P = 0.00047). In conclusion, minor myocardial injury is not uncommon after elective uncomplicated successful PTCA with or without stenting. Cardiac troponins, especially cTnI, are more sensitive than CKMB for the detection of this minor myocardial injury. Total time of inflation and inflation maximal pressure are predictors of postprocedural elevation of cardiac troponins. Side-branch occlusion may account for some, but not all, periprocedural minor myocardial injury.

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Section: Discussionsupporting

confidence: 91%

Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting: Detection by cardiac troponins

Saadeddin

Habbab

Sobki

et al. 2001

Cathet Cardio Intervent

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“…In contrast, La Vecchia et al 10) have reported that the serum TnT level was elevated in most, but not all, of their patients with side branch occlusion treated with coronary stenting. Genser et al 18) reported that all of their patients treated with balloon angioplasty with TnT elevation showed side branch occlusion or major complications. Similar results have also been reported by Ravkilde et al 16) and Talasz et al17) The reason for the absence of any relationship between TnT elevation and angiographically detectable side branch occlusion in our study is obscure.…”

Section: Discussionmentioning

confidence: 99%

Low Incidence of Minor Myocardial Damage Associated with Coronary Stenting Detected by Serum Troponin T Comparable to That with Balloon Coronary Angioplasty.

et al. 1998

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“…The prevalence of cTnI elevation was higher than those of serum CKMB and CK in the BMS group. A higher prevalence of cardiac troponin-T elevation than of CKMB or CK elevation associated with PCI has also been reported [27,28,31]. Furthermore, cTnI has been reported to be more sensitive for detecting myocardial necrosis compared with cardiac troponin-T [23,24,32,33].…”

Section: Discussionmentioning

confidence: 99%

Higher incidence and serum levels of minor cardiac biomarker elevation in sirolimus-eluting stent (Cypher) than bare metal stent implantations

Seitou¹,

Murakami

Komatsubara

et al. 2008

Coronary Artery Disease

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Uncomplicated successful percutaneous transluminal coronary angiopiasty does not affect cardiac troponin T plasma concentrations

Cited by 21 publications

References 5 publications

Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting: Detection by cardiac troponins

Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting: Detection by cardiac troponins

Low Incidence of Minor Myocardial Damage Associated with Coronary Stenting Detected by Serum Troponin T Comparable to That with Balloon Coronary Angioplasty.

Higher incidence and serum levels of minor cardiac biomarker elevation in sirolimus-eluting stent (Cypher) than bare metal stent implantations

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