Uncommon Tumors of the Esophagus

Leichman, Lawrence; Rosser, Robert J.

doi:10.1002/9781118464557.ch27

Cited by 2 publications

(5 citation statements)

References 101 publications

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“…In relation to large cell carcinomas of the oesophagus, too few cases have been reported as yet to be able to draw conclusions regarding best forms of therapy [ 190 ]. One Chinese study including five large cell oesophageal NECs showed that the only statistically significant difference between small cell and large cell groups was age, with large cell tumours being found in older patients [ 144 ].…”

Section: Oesophagusmentioning

confidence: 99%

Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review

et al. 2015

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To date, empirical literature has generally been considered lacking in relation to neuroendocrine carcinomas (NECs), the highly malignant subgroup of neuroendocrine neoplasms. NECs are often found in the lungs or the gastroenteropancreatic (GEP) system and can be of small or large cell type. Concentrating on GEP-NECs, we can conclude that survival times are poor, with a median of only 4–16 months depending on disease stage and primary site. Further, this aggressive disease appears to be on the rise, with incidence numbers increasing while survival times are stagnant. Treatment strategies concerning surgery are often undecided and second-line chemotherapy is not yet established. After an analysis of over 2600 articles, we can conclude that there is indeed more empirical literature concerning GEP-NECs available than previously assumed. This unique review is based on 333 selected articles and contains detailed information concerning all aspects of GEP-NECs. Namely, the classification, histology, genetic abnormalities, epidemiology, origin, biochemistry, imaging, treatment and survival of GEP-NECs are described. Also, organ-specific summaries with more detail in relation to disease presentation, diagnosis, treatment and survival are presented. Finally, key points are discussed with directions for future research priorities.

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Section: Oesophagusmentioning

confidence: 99%

Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review

et al. 2015

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“…Many various terminologies have been used for carcinosarcoma including pseudosarcoma, sarcomatoid carcinoma, spindle cell carcinoma and polypoid carcinoma reflecting the uncertain histogenesis of the tumor. 3 There are three theories regarding the histogenesis of esophageal carcinosarcoma. The first theory is that the spindle cell component is not a malignancy and it is a result of reaction induced by carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Immunohistochemical stain, electron microscopic findings and the common p53 point mutations of both components support the third theory. 3 Most esophageal carcinosarcoma present as large polypoid mass and most frequent symptom is dysphagia. Diagnosis is achieved by biopsy or entire resection of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…cellent treatment option. [3][4][5] Because many cases of esophageal carcinosarcoma have stalks, complete resection of the tumor can be achieved successfully by endoscopic resection. If the tumor is considered as T1N0 stage, endoscopic resection can supersede surgery.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Although esophagectomy is the standard treatment for esophageal carcinosarcoma, endoscopic resection is a less invasive and well tolerable option when the tumor is superficial and has no metastasis. [3][4][5] We present a case of esophageal carcinosarcoma that was treated by endoscopic resection.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Esophageal Carcinosarcoma Treated by Endoscopic Resection

Park

Lee

Jee

et al. 2016

Korean J Helicobacter Up Gastrointest Res

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Esophageal carcinosarcoma is a rare malignant neoplasm that is composed of both carcinomatous and sarcomatous components. A 78-year-old man with esophageal carcinosarcoma presented with dysphagia, and was treated by endoscopic resection. Although surgery is the standard treatment for esophageal carcinosarcoma, endoscopic resection is an excellent alternative when the tumor is superficial and has no metastasis.

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Uncommon Tumors of the Esophagus

Cited by 2 publications

References 101 publications

Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review

Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review

A Case of Esophageal Carcinosarcoma Treated by Endoscopic Resection

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