Uncommon presentation of lichen planopilaris during paclitaxel chemotherapy: Case report

Okwundu, Nwanneka; Ekpo, Felicia; Ghafferi, Jessica; Fivenson, David P.

doi:10.4103/jdds.jdds_44_19

Cited by 1 publication

(2 citation statements)

References 16 publications

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“…The underling mechanism is unknown, but it is thought to be due to autoimmune reactions [1,[4][5][6][7][8][9][10][11][12][13]. Regarding that lichen planus (LP) is grouped as a T-cellmediated autoimmune disease, it can be associated with other autoimmune diseases like systemic lupus erythematosus [6].…”

Section: Introductionmentioning

confidence: 99%

“…Regarding that lichen planus (LP) is grouped as a T-cellmediated autoimmune disease, it can be associated with other autoimmune diseases like systemic lupus erythematosus [6]. Up to now, a few studies have been done to show the comorbidities associated with LPP, either autoimmune diseases or nonautoimmune diseases [2,6,7,[12][13][14][15][16]. Recent studies have shown a relationship between LPP and thyroid disease, especially hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

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Comorbidities in Patients with Lichen Planopilaris: A Case-Control Study

Nasimi

Garmaroudi

Ghiasi

et al. 2022

Skin Appendage Disord

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Introduction: Lichen planopilaris (LPP) is a lymphocyte-mediated type of scarring alopecia and considered to have autoimmune etiology. Studies about systemic comorbid conditions are limited. Our goal is to identify the prevalence of medical comorbidities in patients with LPP. Methods: In a retrospective case-control study, the medical records of 208 LPP patients and 208 controls were reviewed for existing comorbidities such as thyroid diseases, cardiovascular disorders, hypertension, hyperlipidemia, and lupus erythematous. Results: Hyperlipidemia was found in 41.8% of all patients with LPP and in 17.3% of controls (p value <0.001, OR = 4.167). Chances of hypertension and cardiovascular disorders were lower in the LPP group in comparison to controls (p value = 0.009). Thyroid disorders were more prevalent in LPP patients, but the difference was not statistically significant (p value = 0.277). Conclusion: Our study further emphasizes that LPP patients should be screened for medical comorbidities, especially lipid profile abnormalities.

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