Uncommon metastases of invasive lobular breast cancer to the endometrium: a report of two cases and review of the literature

Abstract

Although it is known that breast cancer can metastasize to many organ sites, metastasis to the uterus is uncommon and usually occurs during widespread metastatic disease. Lobular carcinoma is not the most common histological subtypes of breast carcinoma, but it is the most frequent histologic type that causes gastrointestinal, gynecological and peritoneal metastases. The main symptoms of the uterine metastasis depend on the anatomic involvement site. Abnormal uterine bleeding is by far the most important symptom.We highlight the importance of the follow up of patient with breast cancer. A rapid endometrial sampling for confirmation of the diagnosis, should be performed when the routine gynecological follow-up revealed any abnormality. We report two original observations of endometrium metastases of invasive lobular carcinoma of the breast which we detected during follow-up.

Gastric metastasis and peritoneal carcinosis revealing primary breast cancer: an unusual presentation

“…In fact, different histological types of primary breast cancer are associated with different sites of metastasis. Compared with invasive ductal cancer, invasive lobular carcinoma is more likely to have distant metastases, particularly in the GI tract, peritoneum, ovaries and uterus [ 13 , 14 ]. In addition, according to Taal et al, 83% of patients with gastric metastasis had invasive lobular carcinoma [ 6 ], which is consistent with our findings.…”

In vitro Photodynamic Therapy in the Treatment of Endometrial Cancer

“…Another type of endometrial cancer is lobular carcinoma. It is uncommon and most often metastasizes to the gastrointestinal, gynecological and peritoneal tracts [24]. Endometrial tumors are divided into five histological subtypes: endometrioid, serous, mixed (combination of endometrioid and serous), clear cell, and malignant mixed Mullerian tumor.…”

Plexiform tumorlet in a woman with postmenopausal endometrioid endometrial carcinoma taking tamoxifen for breast cancer: A case report

“…Metastatic involvement of the uterine corpus is rare [ 5 ]. It usually occurs in the myometrium and less commonly in the endometrium and leiomyomas [ 6 , 7 ]. Breast carcinoma is the most common metastatic neoplasm, with invasive lobular breast carcinoma accounting for 90% of cases [ 5 ].…”