Unclassified tumor of the gonadal stroma in a pregnant woman

Abstract

Gonadal sex cord stromal tumors contain some of the most morphologically interesting neoplasms of the gonads, and these lead to many important issues in differential diagnosis. Granulosa cell tumors are much more common in females. Unclassified sex cord stromal tumor is rare. We report a case of a 22-year-old woman with acute ruptured unclassified sex cord stromal tumor of the right ovary during pregnancy. The biological behavior of unclassified sex cord stromal tumors resembles that of Sertoli-Leydig cell tumors of intermediate differentiation rather than poorly differentiated tumors, which may have been expected in view of the lack of specific differentiation. This finding is important with regard to postoperative management.

Incidental Adnexal Masses at Cesarean Section

“…Esasen gebelik sırasında rastlanan adneksiyal kitlenin boyutu büyük oranda malignite potansiyeli hakkında fikir vermektedir. [10][11][12] Bizim serimizde malign olan patoloji sonuçları-nın tamamı 8 cm veya üzerinde kitlelerdi. Sekiz cm'nin altındaki kitlelerin tamamının histopatolojik sonucu benign olarak rapor edilmiştir.…”

Relevance of Molecular Pathology for the Diagnosis of Sex Cord–Stromal Tumors of the Ovary: A Narrative Review

“…Few data are available regarding sex cord-stromal tumors NOS, which are defined by the absence of characteristics of a specific tumor type [8]. Indeed, sex cord-stromal tumors of the ovary are difficult to classify in approximately 10% of the cases, due to a low degree of differentiation [202][203][204]. In such cases, the differential diagnosis is usually between adult granulosa cell tumors and SLCTs.…”

“…Generally, tumors are solid or solid and cystic, and have a grey/white to yellow cut section, sometimes with areas of hemorrhage and/or necrosis, and a median size of 6.5 cm (ranging from 0.8 to 20 cm) [8,203,204,206].…”

“…Historically, sex cord-stromal tumors NOS have been divided into two groups: predominance of spindle-shaped cells or predominance of cords/trabecula/tubules that do not allow definitive placement into adult granulosa cell tumor or SLCT categories [202]. Edema and the presence of Leydig or luteinized cells may be observed during pregnancy [203,206]. Tumor cells may show some atypia, with a mitotic count of up to 8 mitoses per 10 HPFs [206].…”

“…Using reticulin stain, the stromal cell component is highlighted by a dense monocellular network, while the sex cord component shows reticulin fiber wrapping nests of sex cord elements or Leydig/luteinized cells during pregnancy [8,203,206].…”