Unchanged Serum Adipokine Concentrations in the Setting of Short-Term Thyroidectomy-Induced Hypothyroidism

Kaplan, Özlem; Üzüm, Ayşe Kubat; Aral, Hale; Uzum, Gungor; Tunalı, Vahit; Demir, Özlem; Planci, Kezban Nur; Kesmezacar, Ozgu; Özbey, Neşe

doi:10.4158/ep12001.or

Cited by 13 publications

(10 citation statements)

References 23 publications

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“…Iglesias et al reported that serum resistin levels were similar in hypothyroid and euthyroid subjects [84]. Kaplan et al demonstrated that no short-term significant changes in resistin, leptin, and adiponectin levels occurred in thyroidectomy-induced hypothyroidism when compared to the euthyroid state [93]. Another study showed a positive association between resistin levels and thyroid hormones [81].…”

Section: Resistinmentioning

confidence: 99%

Adipocytokines in Thyroid Dysfunction

Aydoğan

Şahi̇n

2013

ISRN Inflammation

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Section: Resistinmentioning

confidence: 99%

Adipocytokines in Thyroid Dysfunction

Aydoğan

Şahi̇n

2013

ISRN Inflammation

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“…In group with obese hypothyroidism there is further significant elevation in insulin and blood glucose levels, which could be also explained by reduced glucose metabolism because of diminished insulin depending glucose utilization specially in peripheral tissues as a sequence of impairment in peripheral blood flow [25] . Kapralova et al, demonstrated that increased level of resistin and leptin hormones in cases with subclinical hypothyroidism results in subsequent insulin resistance which results in a compensatory hyperinsulinemia and hyperglycemia [26] .…”

Section: Discussionmentioning

confidence: 99%

Role of Changes in Some Adipokines with Obesity in Relation to Thyroid Function in Early Diagnosed Patients with Subclinical Hypothyroidism

Abozeid¹,

Al-Fattah

Al-Raof

2018

The Medical Journal of Cairo University

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Background: Thyroid hormones can influence energy metabolism. Many patients of obesity have subclinical hypothyroidism and vice versa. Aim of Study:To evaluate the relation of changes in the level adipocyte hormones in obesity and in relation to hypothyroid state in early diagnosed patients with subclinical hypothyroidism. Material and Methods:This work includes 90 females divided into 3 groups each 30 persons (Group I) normal control, (Group II) obese females and (Group III) obese females with early diagnosed subclinical hypothyroidism: BMI were measured and blood samples were collected from all subjects and subjected to determine fasting blood glucose, triglyceride, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDH), TSH, FT4, FT3, insulin level and Interleukin-6 (IL-6). Vaspin, lipocalin 2 and apelin were measured and HOMA IR (homeostatic model assessment) was calculated. Results:In obese patients' body mass index, TSH, fasting blood glucose, fasting insulin, HOMA IR, Interleukin-6, total cholesterol, triglyceride, low-density lipoprotein and apelin, lipocalin 2, vaspin showed a significant increase with a further significant increase in obese with hypothyroidism compared to control group. A significant decrease in high density lipoprotein in obese females with further significant decrease in obese with hypothyroidism, however, the level of FT3 and FT4 are insignificantly reduced in both obese and obese with hypothyroidism compared to control group.Conclusion: It is concluded that obesity released adipokines and inflammation may be part of the axis that has a pathogenic role in the development and progression of hypothyroidism in obese subjects. This open a new point of view that disruption of thyroid function may be one of secondary effect of obesity and that disruption of adipocyte secretion of vaspin, lipocalin 2 and apelin may be implicated in some of the metabolic changes associated with obesity and aggravated with hypothyroid state.

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“…Niektoré popisujú nízke (12,55), ďalšie zas normálne (56-58) alebo aj zvýšené (11) koncentrácie leptínu pri hypertyreóze. Podobne aj pri hypotyreóze boli nájdené jeho zvýšené (55,(58)(59)(60)(61), nezmenené (18)(19)(20)57) alebo dokonca aj znížené hladiny (56). Nárast sérového leptínu bol popísaný i u hypotyreóznych psov (62).…”

Section: Tyreopatie a Leptínunclassified

“…Viaceré štúdie neukazujú žiadnu asociáciu medzi hladinami rezistínu a tyreoidálnymi hormónmi (8,20), niektoré popisujú vysoké (11,(71)(72) koncentrácie rezistínu pri hypertyreóze. Pri hypotyreóze u ľudí boli nájdené nezmenené (73) hladiny.…”

Section: Tyreopatie a Rezistínunclassified

Adipocytokines and thyreopathies

Sotak¹

2020

Vnitr Lek

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Adipocytokíny sú početné proteíny vylučované prevažne tukovým tkanivom. Regulujú mnohé kľúčové fyziologické procesy v ľudskom tele. Zvýšené alebo znížené hladiny tyreoidálnych hormónov pri rôznych tyreopatiách môžu mať vplyv na sérové hladiny jednotlivých adipocytokínov, najmä adiponektínu, rezistínu a visfatínu. Výsledky štúdií sú však kontroverzné alebo chýbajú. Mätúci vplyv môžu mať aj pridružené ochorenia metabolického charakteru (napr. inzulínová rezistencia a diabetes mellitus 2. typu alebo rozvíjajúca sa ateroskleróza).

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Unchanged Serum Adipokine Concentrations in the Setting of Short-Term Thyroidectomy-Induced Hypothyroidism

Cited by 13 publications

References 23 publications

Adipocytokines in Thyroid Dysfunction

Adipocytokines in Thyroid Dysfunction

Role of Changes in Some Adipokines with Obesity in Relation to Thyroid Function in Early Diagnosed Patients with Subclinical Hypothyroidism

Adipocytokines and thyreopathies

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