Uncertainty Potentiates Neural and Cardiac Responses to Visual Stimuli in Anxiety Disorders

Hiser, Jaryd; Schneider, Brett; Koenigs, Michael

doi:10.1016/j.bpsc.2021.02.003

Cited by 6 publications

(3 citation statements)

References 66 publications

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“…Lastly, the sample was relatively small and contained only female participants. Future studies should aim to recruit larger samples from more diverse community or clinical samples (Hiser, Schneider, & Koenigs, 2021).…”

Section: Discussionmentioning

confidence: 99%

Intolerance of uncertainty is associated with heightened responding in the prefrontal cortex during cue-signalled uncertainty of threat

Morriss

Bell

Biagi

et al. 2021

Cogn Affect Behav Neurosci

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Heightened responding to uncertain threat is considered a hallmark of anxiety disorder pathology. We sought to determine whether individual differences in self-reported intolerance of uncertainty (IU), a key transdiagnostic dimension in anxiety-related pathology, underlies differential recruitment of neural circuitry during cue-signalled uncertainty of threat (n = 42). In an instructed threat of shock task, cues signalled uncertain threat of shock (50%) or certain safety from shock. Ratings of arousal and valence, skin conductance response (SCR), and functional magnetic resonance imaging were acquired. Overall, participants displayed greater ratings of arousal and negative valence, SCR, and amygdala activation to uncertain threat versus safe cues. IU was not associated with greater arousal ratings, SCR, or amygdala activation to uncertain threat versus safe cues. However, we found that high IU was associated with greater ratings of negative valence and greater activity in the medial prefrontal cortex and dorsomedial rostral prefrontal cortex to uncertain threat versus safe cues. These findings suggest that during cue-signalled uncertainty of threat, individuals high in IU rate uncertain threat as aversive and engage prefrontal cortical regions known to be involved in safety-signalling and conscious threat appraisal. Taken together, these findings highlight the potential of IU in modulating safety-signalling and conscious appraisal mechanisms in situations with cue-signalled uncertainty of threat, which may be relevant to models of anxiety-related pathology.

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Section: Discussionmentioning

confidence: 99%

Intolerance of uncertainty is associated with heightened responding in the prefrontal cortex during cue-signalled uncertainty of threat

Morriss

Bell

Biagi

et al. 2021

Cogn Affect Behav Neurosci

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show abstract

“…We use adaptive here without a negative or positive connotation, rather to reflect an ecologically driven short-term change in neural circuitry suited to a given environment. The chronic unpredictability and stress of a disadvantaged context may sensitize emotion regulation and uncertainty processing circuitry, yielding less activation of these regions ( 4 , 55 ) as opposed to potentially harmful increases in activity and vigilance to uncertainty observed in anxiety disorders ( 56 ). We hypothesize that the chronic stress associated with greater neighborhood disadvantage may have altered reactivity to predictable stimuli given the endurance needed for maintaining and monitoring predictable and/or negative events in the environment.…”

Section: Discussionmentioning

confidence: 99%

Neighborhood Socioeconomic Disadvantage and the Neurobiology of Uncertainty in Traumatically Injured Adults

Tomas

Webb

Bennett

et al. 2022

Biological Psychiatry Global Open Science

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“…Therefore, the results from this study are not necessarily representative of clinical samples. Future research should address the extent to which these IU-related results in student/community samples are translatable to clinical samples (Gorka et al, 2014;Hiser, Schneider & Koenigs, 2021;Nelson et al, 2016), in order to further understand the relevance of IU as a transdiagnostic dimension in anxiety disorders (Shihata et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Intolerance of uncertainty and physiological responses during instructed uncertain threat: a multi-lab investigation

Morriss¹,

Bradford²,

Biagi³

et al. 2021

Preprint

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Individuals with high self-reported Intolerance of uncertainty (IU) tend to interpret uncertainty negatively. Recent research has been inconclusive on evidence of an association between IU and physiological responses during instructed uncertain threat. To address this gap, we conducted secondary analyses of IU and physiology data recorded during instructed uncertain threat tasks from two lab sites (Wisconsin-Madison; n = 128; Yale, n = 103). Higher IU was associated with: (1) greater corrugator supercilii activity to predictable and unpredictable threat of shock, compared to the safety from shock, and (2) poorer discriminatory skin conductance response between the unpredictable threat of shock, relative to the safety from shock. No IU-related effects were observed for the orbicularis oculi. These findings suggest that IU-related biases may be captured differently depending on the physiological measure during instructed uncertain threat. Implications of these findings for neurobiological models of uncertainty and anticipation in anxiety are discussed.

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Uncertainty Potentiates Neural and Cardiac Responses to Visual Stimuli in Anxiety Disorders

Cited by 6 publications

References 66 publications

Intolerance of uncertainty is associated with heightened responding in the prefrontal cortex during cue-signalled uncertainty of threat

Intolerance of uncertainty is associated with heightened responding in the prefrontal cortex during cue-signalled uncertainty of threat

Neighborhood Socioeconomic Disadvantage and the Neurobiology of Uncertainty in Traumatically Injured Adults

Intolerance of uncertainty and physiological responses during instructed uncertain threat: a multi-lab investigation

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