Uncertainty for reference materials certified by interlaboratory study: Recommendations of an international study group

Ellison, Stephen L. R.; Burke, Sarah E.; Walker, Ronald F.; Heydorn, Κ.; Månsson, M.; Pauwels, J.; Wegscheider, Wolfhard; Nijenhuis, Bauke te

doi:10.1007/s007690100341

Cited by 57 publications

(26 citation statements)

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“…The homogeneity testing protocol was developed from the recommendations of Ellison et al [33]. For each of the AZA CRMs, approximately 3n 1/3 (n; total number of ampoules) of all ampoules produced were selected from over the entire ampoule range.…”

Section: Homogeneity Studymentioning

confidence: 99%

The preparation of certified calibration solutions for azaspiracid-1, -2, and -3, potent marine biotoxins found in shellfish

et al. 2010

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1 AbstractThe production and certification of a series of azaspiracid (AZA) calibration solution reference materials is described. Azaspiracids were isolated from contaminated mussels, purified by preparative liquid chromatography and dried under vacuum to the anhydrous form. Purity was assessed by liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy. Final concentration of each AZA in a CD 3 OH stock solution was determined accurately by quantitative NMR spectroscopy. This solution was then diluted very accurately in degassed, high purity methanol to a concentration of 1.47 ± 0.08 μmol/L for AZA1, 1.52 ± 0.05 μmol/L for AZA2, and 1.37 ± 0.13 μmol/L for AZA3. Aliquots were dispensed into argon-filled glass ampoules, which were immediately flame-sealed. The calibration solutions are suitable for method development, method validation, calibration of liquid chromatography or mass spectrometry instrumentation and quality control of shellfish monitoring programs.2

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Section: Homogeneity Studymentioning

confidence: 99%

The preparation of certified calibration solutions for azaspiracid-1, -2, and -3, potent marine biotoxins found in shellfish

et al. 2010

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“…Figure 2 gives a graphical representation of homogeneity of each of the four candidate RMs, as determined by isotope dilution ICP-MS. The homogeneity testing protocol was developed from the recommendations of Ellison et al [43] For each of the four RMs, 24 samples (i.e., out of the total were selected at random from groups of vials stratified according to the fill order. Given that each vial contains only ca.…”

Section: Lead Concentration Of Reference Materialsmentioning

confidence: 99%

Development of candidate reference materials for the measurement of lead in bone

et al. 2008

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The production of modest quantities of candidate bone lead (Pb) reference materials is described, and an optimized production procedure is presented. The reference materials were developed to enable an assessment of the interlaboratory agreement of laboratories measuring Pb in bone; method validation; and for calibration of solid sampling techniques such as laser ablation ICP-MS. Long bones obtained from Pb-dosed and undosed animals were selected to produce four different pools of a candidate powdered bone reference material. The Pb concentrations of these pools reflect both environmental and occupational exposure levels in humans. The animal bones were harvested post mortem, cleaned, defatted, and broken into pieces using the brittle fracture technique at liquid nitrogen temperature. The bone pieces were then ground in a knife mill to produce fragments of 2-mm size. These were further ground in an ultra-centrifugal mill, resulting in finely powdered bone material that was homogenized and then sampled-scooped into vials. Testing for contamination and homogeneity was performed via instrumental methods of analysis.

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“…The uncertainty components related to the long-term stability of this CRM were also calculated according to the recommendations of an international study group [20]. MOOS-1 has been continuously monitored since 1996 and found to be stable with respect to nutrient concentration over this period.…”

Section: Stabilitymentioning

confidence: 99%

“…The uncertainty components for homogeneity were derived according to the recommendation of an international study group [20]. The material was tested for homogeneity at NRC using standard colorimetric procedures.…”

Section: Homogeneitymentioning

confidence: 99%

Preparation and certification of a reference material for the determination of nutrients in seawater

Clancy

Willie

2004

Analytical and Bioanalytical Chemistry

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There is an urgent need for natural water reference materials certified for nutrients. In 1996, NRC collected seawater for a proposed CRM at a depth of 200 m in the North Atlantic; this was immediately filtered through 0.05-microm cartridge filters into 50-L carboys. The water was later homogenized in the NRC laboratories in Ottawa and stabilized via gamma irradiation. Over six years of stability testing no significant deterioration was detected. In addition to the usual customary standard colorimetric procedures, alternative analytical methods were developed to enable the certification process. The production of a CRM called MOOS-1 will be discussed. Certified values, with uncertainty components addressing the homogeneity, stability, and characterization of the material, were calculated to be: orthophosphate=1.56+/-0.07 micro mol L(-1), silicate=26.0+/-1.0 micro mol L(-1), nitrite=3.06+/-0.15 micro mol L(-1), and nitrite and nitrate=23.7+/-0.9 micro mol L(-1).

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Uncertainty for reference materials certified by interlaboratory study: Recommendations of an international study group

Cited by 57 publications

References 0 publications

The preparation of certified calibration solutions for azaspiracid-1, -2, and -3, potent marine biotoxins found in shellfish

The preparation of certified calibration solutions for azaspiracid-1, -2, and -3, potent marine biotoxins found in shellfish

Development of candidate reference materials for the measurement of lead in bone

Preparation and certification of a reference material for the determination of nutrients in seawater

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